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Calbindin immunoreactivity alternates with cytochrome c-oxidase-rich zones in some layers of the primate visual cortex

Nature volume 323, pages 715–717 (1986)Cite this article

Abstract

Calcium ions have a pivotal role in many neuronal activities1, but little is known about their involvement in the cortical processing of visual information2. Using immunohistochemical methods, we have now detected a calcium-binding protein, calbindin-D-28K (ref. 3, calbindin), which may confer on certain compartments of cortical area 17 the ability to modulate Ca2+ metabolism. Thus, calbindin occurs in the primate striate cortex in a pattern almost complementary to that displaying strong cytochrome c-oxidase activity. From this and other observations, we deduce that the distribution of calbindin-immunoreactive sites corresponds mainly to extra-geniculocortical connections of the primary visual cortex. This implies that the geniculocortical and extra-geniculocortical compartments of area 17 differ in an intracellular system for Ca2+ homeostasis.

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References

  1. Kretsinger, R. H. Neurosci. Res. Prog. Bull. 19, 213–328 (1981).

    Google Scholar 

  2. Singer, W. Vision Res. 25, 389–396 (1985).

    Article  CAS  Google Scholar 

  3. Wassermann, R. H. in Vitamin D (eds Norman, A. W., Schaefer, K., Grigolet, H. G. & Herrath, D.) 321 (De Gruyter, Berlin, 1985).

    Google Scholar 

  4. Wassermann, R. H. & Taylor, A. N. Science 152, 791 (1966).

    Article  ADS  Google Scholar 

  5. Norman, A. W., Roth, J. & Orci, L. Endocr. Rev. 3, 331–366 (1982).

    Article  CAS  Google Scholar 

  6. Wassermann, R. H. & Fullmer, C. S. in Calcium and Cell Function (ed. Cheung, W.) 175 (Academic, New York, 1982).

    Book  Google Scholar 

  7. Baimbridge, K. G. & Miller, J. J. Brain Res. 324, 85–90 (1984).

    Article  CAS  Google Scholar 

  8. Christakos, S., Friedlander, E. J., Frandsen, B. R. & Norman, A. W. Endocrinology 104, 1495 (1979).

    Article  CAS  Google Scholar 

  9. Carroll, E. W. & Wong-Riley, M. T. T. J. comp. Neurol. 222, 1 (1984).

    Article  CAS  Google Scholar 

  10. Macchi, G. & Bentivoglio, M. Ital. J. neurol. Sci. 2, 83–96 (1982).

    Article  Google Scholar 

  11. Tigges, J. & Tigges, M. in Cerebral Cortex Vol. 3 (eds Peters, A. & Jones, E. G.) 351–378 (Plenum, New York, 1985).

    Google Scholar 

  12. Doty, R. W. J. comp. Neurol. 218, 159 (1983).

    Article  CAS  Google Scholar 

  13. Van Essen, D. C. in Cerebral Cortex Vol. 3 (eds Peters, A. & Jones, E. G.) 259 (Plenum, New York, 1985).

    Google Scholar 

  14. Celio, M. R. & Norman, A. W. Anat. Embryol. 173, 143–148 (1985).

    Article  CAS  Google Scholar 

  15. Garcia-Segura, L. M., Baetens, D., Roth, J., Norman, A. W. & Orci, L. Brain Res. 296, 75–86 (1984).

    Article  CAS  Google Scholar 

  16. Heizmann, C. W. Experientia 40, 910–921 (1984).

    Article  CAS  Google Scholar 

  17. Hubel, D. Nature 299, 515–524 (1982).

    Article  ADS  CAS  Google Scholar 

  18. Celio, M. R., Schärer, L., Morrison, J. H., Norman, A. W. & Bloom, F. E. Soc. Neurosci. Abstr. 10, 1 (1983).

    Google Scholar 

  19. Wong-Riley, M. Brain Res. 171, 11 (1979).

    Article  CAS  Google Scholar 

  20. Livingstone, M. S. & Hubel, D. H. Proc. natn. Acad. Sci. U.S.A. 79, 6098 (1982).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Anatomy, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland

    Marco R. Celio & L. Schärer

  2. Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA

    John H. Morrison & F. E. Bloom

  3. Department of Biochemistry, University of California at Riverside, Riverside, California, 9251, USA

    A. W. Norman

Authors
  1. Marco R. Celio
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  2. L. Schärer
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  3. John H. Morrison
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  4. A. W. Norman
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  5. F. E. Bloom
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Celio, M., Schärer, L., Morrison, J. et al. Calbindin immunoreactivity alternates with cytochrome c-oxidase-rich zones in some layers of the primate visual cortex. Nature 323, 715–717 (1986). https://doi.org/10.1038/323715a0

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