Abstract
The search for the genes encoding the T-cell receptor α and β chains revealed a third gene, Tγ (ref. 1), which shares with the Tα (refs 2–7) and Tβ (refs 8–15) genes a number of structural features, including somatic rearrangement during T-cell development. Tγ gene expression appears to be unnecessary in some mature T cells16,17 and is at its greatest in fetal thymocytes18,19, encouraging speculation that Tγ has a role in T-cell development and may be involved in the recognition of polymorphic major histocompatibility complex (MHC) products during thymic education20,21. One argument against the participation of Tγ in such a process has been its apparently limited diversity, due to the small number of gene segments available for rearrangement1,22. We here describe the identification of additional Tγ V-gene segments and demonstrate that they can be rearranged to previously identified J- and C-gene segments and are expressed in fetal thymocytes. In addition we describe a variety of patterns of Tγ mRNA processing which may be significant for Tγ gene regulation.
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Heilig, J., Tonegawa, S. Diversity of murine gamma genes and expression in fetal and adult T lymphocytes. Nature 322, 836–840 (1986). https://doi.org/10.1038/322836a0
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DOI: https://doi.org/10.1038/322836a0
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