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Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

Nature volume 320, pages 277–280 (1986)Cite this article

Abstract

A role for proto-oncogenes in the regulation and modulation of cell proliferation1,2 has been suggested by the findings that the B-chain of platelet-derived growth factor (PDGF) is encoded by the proto-oncogene sis3–7 and that the erb-B oncogene product is a truncated form of the epidermal growth factor (EGF) receptor8–10. Furthermore, the product of the proto-oncogene fms (c-fms) may be related or identical to the receptor for macrophage colony-stimulating factor (CSF-1)11. v-fms is the transforming gene of the McDonough strain of feline sarcoma virus (SM-FeSV)12,13 and belongs to the family of src-related oncogenes which have tyrosine-specific kinase activity. Furthermore, nucleo-tide sequence analysis of the v-fms gene product revealed topologi-cal properties of a cell-surface receptor protein14. To elucidate the features involved in the conversion of a normal cell-surface receptor gene into an oncogenic one, we have now determined the complete nucleotide sequence of a human c-fms complementary DNA. The 972-amino-acid c-fms protein has an extracellular domain, a membrane-spanning region, and a cytoplasmic tyrosine protein kinase domain. Comparison of the feline v-fms and human c-fms sequences reveals that the proteins share extensive homology but have different carboxyl termini.

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References

  1. Bishop, J. M. Cell 42, 23–28 (1985).

    Article  CAS  PubMed  Google Scholar 

  2. Muller, R. & Verma, I. M. Curr. Topics Microbiol. Immun. 112, 73–115 (1984).

    CAS  Google Scholar 

  3. Doolittle, R. F. et al. Science 221, 275–277 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Waterfield, M. D. et al. Nature 304, 35–39 (1983).

    ADS  CAS  PubMed  Google Scholar 

  5. Devare, S. G., Reddy, E. P., Law, J. D., Robbins, K. C. & Aaronson, S. A. Proc. natn. Acad. Sci. U.S.A. 80, 731–735 (1983).

    Article  ADS  CAS  Google Scholar 

  6. Hunter, T. Trends biochem. Sci. 10, 275–280 (1985).

    Article  CAS  Google Scholar 

  7. Van Beveren, C. & Verma, I. M. Curr. Topics Microbiol. Immun. 123, 73–98 (1985).

    Google Scholar 

  8. Ullrich, A. et al. Nature 309, 418–425 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Xu, Y.-H. et al. Nature 309, 806–810 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Lin, C. R. et al. Science 224, 843–848 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Sherr, C. J. et al. Cell 41, 665–676 (1985).

    Article  CAS  PubMed  Google Scholar 

  12. Donner, L., Fedele, L. A., Garon, C. F., Anderson, S. J. & Sherr, C. J. J Virol. 41, 489–500 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Heisterkamp. N. et al. Virology 126, 248–258 (1983).

    Article  CAS  PubMed  Google Scholar 

  14. Hampe, A., Gobet, M., Sherr, C. J. & Galibert, F. Proc. natn. Acad. Sci. U.S.A. 81, 85–89 (1984).

    Article  ADS  CAS  Google Scholar 

  15. Kozak, M. Microbiol. Rev. 47, 1–45 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Wickner, W. T. & Lodish, H. F. Science 230, 400–407 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Rettenmier, C. W. et al. Science 228, 320–322 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Pfeffer, S. & Ullrich, A. Nature 313, 184 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  19. Ullrich, A. et al. Nature 313, 756–761 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Yamamoto, T. et al. Cell 39, 27–38 (1984).

    Article  CAS  PubMed  Google Scholar 

  21. Morgan, C. J. & Stanley, E. R. Biochem. biophys. Res. Commun. 119, 35–41 (1984).

    Article  CAS  PubMed  Google Scholar 

  22. Neckameyer, W. S. & Wang, L.-H. J Virol. 53, 879–884 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Downward, J., Parker, P. & Waterfield, M. D. Nature 311, 483–485 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. Takeya, T. & Hanafusa, H. Cell 32, 881–890 (1983).

    Article  CAS  PubMed  Google Scholar 

  25. Gray, A., Dull, T. J. & Ullrich, A. Nature 303, 722–725 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Huyng, T. et al. Practical Approaches in Biochemistry (ed. Grover, D.) (Information Retrievable Ltd, Oxford, 1984).

    Google Scholar 

  27. Taylor, J. M. et al. Biochim. biophys. Acta 4, 324–330 (1976).

    Article  Google Scholar 

  28. Southern, E. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  PubMed  Google Scholar 

  29. Messing, J., Crea, R. & Seeburg, P. H. Nucleic Acids Res. 9, 309–321 (1981).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Laprevotte, I., Hampe, A., Sherr, C. J. & Galibert, F. J. Virol. 50, 884–894 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

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Author notes

  1. Charles Van Beveren, Richard L. Mitchell, Clare M. Isacke and Inder M. Verma: Molecular Biology and Virology Laboratory, Salk Institute, PO Box 85800, San Diego, California 92138, USA

Authors and Affiliations

  1. Department of Molecular Biology, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    Lisa Coussens, Charles Van Beveren, Douglas Smith, Ellson Chen, Richard L. Mitchell, Clare M. Isacke, Inder M. Verma & Axel Ullrich

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  1. Lisa Coussens
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  2. Charles Van Beveren
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  4. Ellson Chen
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  6. Clare M. Isacke
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  7. Inder M. Verma
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  8. Axel Ullrich
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Coussens, L., Van Beveren, C., Smith, D. et al. Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. Nature 320, 277–280 (1986). https://doi.org/10.1038/320277a0

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