Abstract
Antigen recognition by human T lymphocytes and initiation of T-cell activation are mediated by a group of integral membrane proteins, the T-cell antigen receptor (TCR) and the T3 complex1–8. The polypeptides which comprise T3 (a γ-chain of relative molecular mass (Mr) 25,000 (25K), and δ and ε chains of 20K each) are physically associated with the TCR chains9–12. Surface expression of the complex requires the presence of all the com-ponent T3 and TCR proteins13. In contrast to the human system, murine T3 has not been identified using antibodies. Here we describe a murine T3-like protein complex. It appears to be more complicated than human T3, containing three monomeric glyco-proteins (21–28K), two of which have N-linked carbohydrate side chains and a novel family of TCR-associated homo- and heterodimers. The 28K protein is identified as the murine T3 δ-chain. The 21K protein is phosphorylated on cell activation with concanavalin A (Con A)
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Oettgen, H., Pettey, C., Maloy, W. et al. A T3-like protein complex associated with the antigen receptor on murine T cells. Nature 320, 272–275 (1986). https://doi.org/10.1038/320272a0
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DOI: https://doi.org/10.1038/320272a0
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