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Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors

Nature volume 318, pages 149–154 (1985)Cite this article

Abstract

Bone marrow cells infected with retroviral vectors carrying the bacterial neomycin resistance (neo) gene as a marker were used for long-term reconstitution of the haematopoietic system of irradiated mice. The neo gene is expressed in the myeloid and lymphoid lineages of these animals and an analysis of the sites of viral integration indicates that these lineages are derived from the same primitive multipotent cells.

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Authors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005, Basel, Switzerland

    Gordon Keller & Christopher Paige

  2. Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA

    Eli Gilboa

  3. European Molecular Biology Laboratory, Meyerhofstrasse 1, D-6900, Heidelberg, FRG

    Erwin F. Wagner

Authors
  1. Gordon Keller
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  2. Christopher Paige
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  3. Eli Gilboa
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  4. Erwin F. Wagner
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Keller, G., Paige, C., Gilboa, E. et al. Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors. Nature 318, 149–154 (1985). https://doi.org/10.1038/318149a0

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  • DOI: https://doi.org/10.1038/318149a0

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