Abstract
Induction of mammary carcinomas in rats by a single exposure to a carcinogen during sexual development often involves malignant activation of the Ha-ras-1 locus. Each of the Ha-ras-1 oncogenes present in tumours induced by N-nitroso-N-methylurea, but not in those induced by 7,12-dimethylbenz(a)anthracene, became activated by the same G → A transition, the type of mutation induced by N-nitroso-N-methylurea. These results are consistent with the notion that Ha-ras-1 oncogenes are directly activated by the carcinogen during initiation of neoplasia.
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References
Sukumar, S., Notario, V., Martin-Zanca, D. & Barbacid, M. Nature 306, 658–661 (1983).
Balmain, A. & Pragnell, I. B. Nature 303, 72–74 (1983).
Eva, A. & Aaronson, S. A. Science 220, 955–956 (1983).
Guerrero, I., Calzada, P., Mayer, A. & Pellicer, A. Proc. natn. Acad. Sci. U.S.A. 81, 202–205 (1984).
Padhy, L. C., Shih, C., Cowing, D., Finkelstein, R. & Weinberg, R. A. Cell 28, 865–871 (1982).
Parada, L. F. & Weinberg, R. A. Molec. cell. Biol. 3, 2298–2301 (1983).
Sukumar, S. et al. Science 223, 1197–1199 (1984).
Guerrero, I., Villasante, A., Corces, V. & Pellicer, A. Science 225, 1159–1162 (1984).
Balmain, A., Ramsden, M., Bowden, G. T. & Smith, J. Nature 307, 658–660 (1984).
Gullino, P. M., Pettigrew, H. M. & Grantham, F. H. J. natn. Cancer Inst. 54, 401–409 (1975).
Singer, B. & Kusmierek, J. T. A. Rev. Biochem. 51, 655–693 (1982).
Pegg, A. E. Cancer Invest. 2, 223–231 (1984).
Conner, B. J. et al. Proc. natn. Acad. Sci. U.S.A. 80, 278–282 (1983).
Southern, P. J. & Berg, P. J. molec. appl. Genet. 1, 327–341 (1982).
Yuasa, Y. et al. Nature 303, 775–779 (1983).
Taparowsky, E., Shimizu, K., Goldfarb, M. & Wigler, M. Cell 34, 581–586 (1983).
Dhar, R. et al. Science 217, 934–937 (1982).
McCormick, D. L., Adamowski, C. B., Fiks, A. & Moon, R. C. Cancer Res. 41, 1690–1694 (1981).
Newbold, R. F. & Overell, R. W. Nature 304, 648–651 (1983).
Land, H., Parada, L. F. & Weinberg, R. A. Nature 304, 596–602 (1983).
Ruley, H. E. Nature 304, 602–606 (1983).
Spandidos, D. A. & Wilkie, N. M. Nature 310, 469–475 (1984).
Southern, E. M. J. molec. Biol. 98, 503–517 (1975).
Kidd, V. J., Wallace, R. B., Itakura, K. & Woo, S. L. C. Nature 304, 230–234 (1983).
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Zarbl, H., Sukumar, S., Arthur, A. et al. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature 315, 382–385 (1985). https://doi.org/10.1038/315382a0
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DOI: https://doi.org/10.1038/315382a0
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