Abstract
The T-cell receptor for antigen has been identified as a disulphide-linked heterodimeric glycoprotein of relative molecular mass (Mr) 90,000 comprising an α- and a β-chain1–3. The availability of complementary DNA clones encoding mouse4 and human5 β-chains has allowed a detailed characterization of the genomic organization of the β-chain gene family and has revealed that functional β-chain genes in T cells are generated from recombination events involving variable (V), diversity (D), joining (J) and constant (C) gene segments6,7. Recently, cDNA clones encoding mouse8,9 and human10 α-chains have been described; the sequences of these clones have indicated that functional α-chain genes are also generated from multiple gene segments. It is possible that chromosomal translocations involving T-cell receptor α- and β-chain genes have a role in T-cell neoplasms in much the same way as translocations involving immunoglobulin genes are associated with oncogenic transformation in B cells11. In the latter case, the chromosomal localization of the immunoglobulin genes provided one of the first indications of the involvement of such translocations in oncogenic transformation. The chromosomal assignment of the α- and β-chain genes may, therefore, provide equally important clues for T-cell neoplastic transformation. The chromosomal location of the mouse and human β-chain gene family has been determined: the murine gene lies on chromosome 6 (refs 12, 13) whereas the human gene is located on chromosome 7 (refs 13,14). Here we use a cDNA clone encoding the human α-chain to map the corresponding gene to chromosome 14.
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References
Allison, J. P., McIntyre, B. W. & Bloch, D. J. Immun. 129, 2293–2300 (1982).
Haskins, K. et al. J. exp. Med. 157, 1149–1169 (1983).
Meuer, S. C. et al. J. exp. Med. 157, 705–719 (1983).
Hedrick, S. M., Nielsen, E. A., Kavaler, J., Cohen, D. I. & Davis, M. M. Nature 308, 153–158 (1984).
Yanagi, Y. et al. Nature 308, 145–149 (1984).
Chien, Y., Gascoigne, N. R. J., Kavaler, J., Lee, N. E. & Davis, M. M. Nature 309, 322–326 (1984).
Siu, G. et al. Cell 37, 393–401 (1984).
Saito, H. et al. Nature 312, 36–40 (1984).
Chien, Y. et al. Nature 312, 31–35 (1984).
Sim, G. K. et al. Nature 312, 771–775 (1984).
Perry, R. P. Cell 33, 647–650 (1983).
Lee, N. E. et al. J. exp. Med. 160, 905–913 (1984).
Caccia, N. et al. Cell 37, 1091–1099 (1984).
Collins, M. K. L. et al. EMBO J. 3, 2347–2349 (1984).
Collins, M. K. L. et al. EMBO J. (submitted).
Croce, C. M. et al. Proc. natn. Acad. Sci. U.S.A. 76, 3416–3419 (1979).
Barker, P. E. et al. Proc. natn. Acad. Sci. U.S.A. 81, 5826–5830 (1984).
Ferguson-Smith, M. A. & Cox, D. R. Cytogenet. Cell Genet. 37, 127–154 (1984).
Giblett, E. L., Ammann, A. J., Wara, D. W., Sandman, R. & Diamond, L. K. Lancet i, 1010–1013 (1975).
Dembić, Z., Bannwarth, W., Taylor, B. A. & Steinmetz, M. Nature 314, 271–273 (1985).
Kranz, D. et al. Science (in the press).
Zech, L. et al. Nature 308, 858–860 (1984).
Ueshima, Y., Rowley, J. D., Varikujis, D., Winter, J. & Gordon, L. Blood 63, 1028–1038 (1984).
Hecht, E., Morgan, R., Hecht, B. K-M. & Smith, S. D. Science 226, 1445–1447 (1984).
Solomon, E. et al. Somat. Cell Genet. 2, 125–140 (1976).
Jones, E. A., Goodfellow, P. N., Kennen, R. H. & Bodmer, W. F. Somat. Cell Genet. 2, 483–496 (1976).
Whitehead, A. S. et al. Proc. natn. Acad. Sci. U.S.A. 79, 5021–5025 (1982).
Nabholz, M., Giggiano, J. & Bodmer, W. F. Nature 223, 358–363 (1969).
Van Heyningen, V. et al. Ann. hum. Genet. 38, 295–303 (1975).
Tunnacliffe, A. & Goodfellow, P. in Genetic Analysis of the Cell Surface, Receptors and Recognition Vol. 16 (ed. Goodfellow, P.) 57–82 (Chapman & Hall, London, 1984).
Sykes, B. & Solomon, E. Nature 272, 548–549 (1978).
Solomon, E. et al. Cytogenet. Cell Genet. 35, 64–66 (1983).
Croce, C. M. & Koprowski, H. J. exp. Med. 140, 1221–1229 (1974).
Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratory, New York, 1982).
Feinberg, A. O. & Vogelstein, B. Analyt. Biochem. 137, 266–267 (1984).
Harris, H. & Hopkinson, D. A. Handbook of Enzyme Electrophoresis in Human Genetics Suppl. 1977-78 (North-Holland, Amsterdam, 1976).
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Collins, M., Goodfellow, P., Spurr, N. et al. The human T-cell receptor α-chain gene maps to chromosome 14. Nature 314, 273–274 (1985). https://doi.org/10.1038/314273a0
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DOI: https://doi.org/10.1038/314273a0
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