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Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

Abstract

The adenovirus-2 early region 1A (E1A) products repress activation of transcription induced by the simian virus 40, polyoma virus and adenovirus-2 E1A enhancers. The repression probably involves an interaction between the enhancer elements and a trans-acting factor(s), possibly the E1A products themselves.

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References

  1. Yaniv, M. Nature 297, 17–18 (1982).

    Article  ADS  CAS  Google Scholar 

  2. Khoury, G. & Gruss, P. Cell 33, 313–314 (1983).

    Article  CAS  Google Scholar 

  3. Wasylyk, B., Wasylyk, C., Augereau, P. & Chambon, P. Cell 32, 503–514 (1983).

    Article  CAS  Google Scholar 

  4. Chambon, P. et al. Recent Prog. Horm. Res. 40, 1–42 (1984).

    CAS  PubMed  Google Scholar 

  5. Hen, R., Sassone-Corsi, P., Corden, J., Gaub, M. P. & Chambon, P. Proc. natn. Acad. Sci. U.S.A. 79, 7132–7136 (1982).

    Article  ADS  CAS  Google Scholar 

  6. Banerji, J., Olson, L. & Schaffner, W. Cell 33, 729–740 (1983).

    Article  CAS  Google Scholar 

  7. Gillies, S. D., Morrison, S. L., Oi, V. T. & Tonegawa, S. Cell 33, 717–728 (1983).

    Article  CAS  Google Scholar 

  8. Chandler, V. L., Maler, B. A. & Yamamoto, K. R. Cell 33, 489–499 (1983).

    Article  CAS  Google Scholar 

  9. Sassone-Corsi, P., Dougherty, J. P., Wasylyk, B. & Chambon, P. Proc. natn. Acad. Sci. U.S.A. 81, 308–312 (1984).

    Article  ADS  CAS  Google Scholar 

  10. Wildeman, A. G., Sassone-Corsi, P., Grundström, T., Zenke, M. & Chambon, P. EMBO J. (in the press).

  11. Sassone-Corsi, P., Wildeman, A. & Chambon, P. Nature (in the press).

  12. Sassone-Corsi, P., Hen, R., Borrelli, E., Leff, T. & Chambon, P. Nucleic Acids Res. 11, 8735–8745 (1983).

    Article  CAS  Google Scholar 

  13. Flint, S. J. Biochim. biophys. Acta 651, 175–208 (1982).

    CAS  PubMed  Google Scholar 

  14. Cross, F. R. & Darnell, J. E. J. Virol. 45, 683–692 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Leff, T. et al. Proc. natn. Acad. Sci. U.S.A. 81, 4381–4385 (1984).

    Article  ADS  CAS  Google Scholar 

  16. Pettersson, U. & Akusjärvi, G. in Advances in Viral Oncology Vol. 3 (ed. Klein, G.) 83–131 (Raven, New York, 1983).

    Google Scholar 

  17. Ruley, H. E. Nature 304, 602–606 (1983).

    Article  ADS  CAS  Google Scholar 

  18. Montell, C., Coutois, G., Eng, C. & Berk, A. Cell 36, 951–961 (1984).

    Article  CAS  Google Scholar 

  19. Schrier, P. I., Bernards, R., Vaessen, R. T. M. J., Houweling, A. & Van der Eb, A. J. Nature 305, 771–775 (1983).

    Article  ADS  CAS  Google Scholar 

  20. Green, M. R., Triesman, R. & Maniatis, T. Cell 35, 137–148 (1983).

    Article  CAS  Google Scholar 

  21. Treisman, R., Green, M. R. & Maniatis, T. Proc. natn. Acad. Sci. U.S.A. 80, 7428–7432 (1983).

    Article  ADS  CAS  Google Scholar 

  22. Svensson, C. & Akusjärvi, G. EMBO J. 3, 789–794 (1984).

    Article  CAS  Google Scholar 

  23. Hen, R., Borrelli, E., Sassone-Corsi, P. & Chambon, P. Nucleic Acids Res. 11, 8748–8760.

  24. Hearing, P. & Shenk, T. Cell 33, 695–703 (1983).

    Article  CAS  Google Scholar 

  25. Imperiale, M. J., Feldman, L. T. & Nevins, J. R. Cell 35, 127–136 (1983).

    Article  CAS  Google Scholar 

  26. Gaynor, R. B., Hillman, D. & Berk, A. J. Proc. natn. Acad. Sci. U.S.A. 81, 1193–1197 (1984).

    Article  ADS  CAS  Google Scholar 

  27. Weiher, H., König, M. & Gruss, P. Science 219, 626–631 (1983).

    Article  ADS  CAS  Google Scholar 

  28. Jongstra, J. et al. Nature 307, 708–714 (1984).

    Article  ADS  CAS  Google Scholar 

  29. Berk, A. J., Lee, F., Harrison, T., Williams, J. & Sharp, P. A. Cell 17, 935–944 (1979).

    Article  CAS  Google Scholar 

  30. Nevins, J. R. Cell 26, 213–220 (1981).

    Article  CAS  Google Scholar 

  31. Myers, R. M., Rio, D. C., Robbins, A. K. & Tjian, R. Cell 25, 373–384 (1981).

    Article  CAS  Google Scholar 

  32. Keller, J. M. & Alwine, J. C. Cell 36, 381–389 (1984).

    Article  CAS  Google Scholar 

  33. Vasseur, M., Katinka, M., Herbomel, P., Yaniv, M. & Blangy, D. J. Virol. 43, 800–808 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Linney, E. & Donerly, S. Cell 35, 693–699 (1983).

    Article  CAS  Google Scholar 

  35. Herbomel, P., Bourachot, B. & Yaniv, M. Cell (in the press).

  36. Imperiale, M. J., Kao, H. T., Feldman, L. T., Nevins, J. R. & Strickland, S. Molec. cell. Biol. 4, 867–874 (1984).

    Article  CAS  Google Scholar 

  37. DeVilliers, J. & Schaffner, W. Nucleic Acids Res. 9, 6251–6264 (1981).

    Article  CAS  Google Scholar 

  38. Van Ooyen, A., Van den Berg, J., Mantei, N. & Weissman, C. Science 206, 337–344 (1979).

    Article  ADS  CAS  Google Scholar 

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Borrelli, E., Hen, R. & Chambon, P. Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription. Nature 312, 608–612 (1984). https://doi.org/10.1038/312608a0

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