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Molecular cloning of a new transforming gene from a chemically transformed human cell line

Abstract

Molecular cloning of the transforming gene from a chemically transformed human osteosarcoma-derived cell line enables the gene to be mapped to chromosome 7 (7p11.4–7qter) and by this criterion and by direct hybridization to be shown to be unrelated to known oncogenes.

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References

  1. Balmain, A. & Pragnell, I. B. Nature 303, 72–74 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Balmain, A., Ramsden, M., Bowden, G. T. & Smith, V. Nature 307, 658–660 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Sukumar, S., Notario, V., Martin-Zarca, D. & Barbacid, M. Nature 306, 658–661 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Sukumar, S. et al. Science 223, 1197–1199 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Eva, A. & Aaronson, S. A. Science 220, 955–956 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Parada, L. F. & Weinberg, R. A. Molec. cell. Biol. 3, 2298–2301 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Guernero, I., Caleada, P., Mayer, A. & Pellicer, A. Proc. natn. Acad. Sci. U.S.A. 81, 202–205 (1984).

    Article  ADS  Google Scholar 

  8. Henry, S. A. Br. med. Bull. 4, 389–401 (1947).

    Article  CAS  Google Scholar 

  9. USPHS Publ. (HEW) 79-50066 (US Dept of Health, Education and Welfare, Washington, DC, 1979).

  10. Renwick, A. G. & Drasan, B. S. Nature 263, 234–235 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Kakunaga, T. Proc. natn. Acad. Sci. U.S.A. 75, 1334–1338 (1978).

    Article  ADS  CAS  Google Scholar 

  12. Rhim, J. S. et al. J. natn. Cancer Inst. 55, 1291–1294 (1975).

    Article  CAS  Google Scholar 

  13. Rhim, J. S., Park, D. K., Arnstein, P., Huebner, R. J. & Weisburger, E. K. Nature 256, 751–753 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. DiPaolo, J. A. J. natn. Cancer Inst. 70, 3–8 (1983).

    CAS  Google Scholar 

  15. Blair, D. G., Cooper, C. S., Oskarsson, M. K., Eader, L. A. & Vande Woude, G. F. Science 218, 1122–1125 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Cooper, C. S. et al. Cancer Res. 44, 1–10 (1984).

    CAS  PubMed  Google Scholar 

  17. Southern, E. M. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  PubMed  Google Scholar 

  18. Jelinek, W. R. et al. Proc. natn. Acad. Sci. U.S.A. 77, 1398–1402 (1980).

    Article  ADS  CAS  Google Scholar 

  19. Shimizu, K. et al. Proc. natn. Acad. Sci. U.S.A. 80, 2112–2116 (1983).

    Article  ADS  CAS  Google Scholar 

  20. Hall, A., Marshall, C. J., Spurr, N. K. & Weiss, R. Nature 303, 376–400 (1983).

    ADS  Google Scholar 

  21. Diamond, A., Cooper, G. M., Ritz, J. & Lane, M. A. Nature 305, 112–116 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  22. Chang, E. H., Gonda, M. A., Ellis, R. W., Scolnick, E. M. & Lowy, D. R. Proc. natn. Acad. Sci. U.S.A. 79, 4848–4852 (1982).

    Article  ADS  CAS  Google Scholar 

  23. Watson, R., Oskarsson, M. & Vande Woude, G. F. Proc. natn. Acad. Sci. U.S.A. 79, 4078–4082 (1982).

    Article  ADS  CAS  Google Scholar 

  24. Dalla Favera, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6497–6501 (1982).

    Article  ADS  CAS  Google Scholar 

  25. Heisterkamp, N., Groffen, J. & Stephenson, J. R. J. molec. appl. Genet. 2, 57–68 (1983).

    CAS  Google Scholar 

  26. Josephs, S. F., Dalla Favera, R., Gelmann, E. P., Gallo, R. C. & Wong-Staal, F. Science 219, 503–505 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  27. Groffen, J., Heisterkamp, N., Grosveld, F., Van de Ven, W. & Stephenson, J. R. Science 216, 1136–1138 (1983).

    Article  ADS  Google Scholar 

  28. Dalla-Favera, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7824–7827 (1982).

    Article  ADS  CAS  Google Scholar 

  29. Croce, C. M. & Koprowski, H. J. exp. Med. 139, 1350–1353 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Knowles, B. A. et al. J. exp. Med. 145, 314–326 (1977).

    Article  CAS  PubMed  Google Scholar 

  31. Croce, C. M., Aden, D. & Koprowski, H. Science 190, 1200–1202 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  32. Gilden, R. V., Rice, N. R. & McAllister, R. M. Gene Analysis Tech. 1, 23–33 (1984).

    Article  Google Scholar 

  33. Spurr, N. K. et al. EMBO J. 3, 159–163 (1984).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Vennstrom, B., Fanshier, L., Moscovici, C. & Bishop, J. M. J. Virol. 36, 575–585 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Jansson, M., Philipson, L. & Vennstrom, B. EMBO J. 2, 561–565 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Rowley, J. D. & Testa, J. R. Adv. Cancer Res. 36, 103–148 (1982).

    Article  CAS  PubMed  Google Scholar 

  37. Appendix 1: Cancer Genet. Cytogenet. 11, 300–303 (1984).

  38. Yunis, J. J. Cancer Genet. Cytogenet. 11, 125–137 (1984).

    Article  CAS  PubMed  Google Scholar 

  39. Ray, J. H. & German, J. in Genes, Chromosomes and Neoplasia (eds Arrighi, F. E., Rao, P. N. & Stubblefield, E.) 351–376 (Raven, New York, 1981).

    Google Scholar 

  40. Pulciani, S. et al. Nature 300, 539–542 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  41. Der, C. J. & Cooper, G. M. Cell 32, 201–208 (1983).

    Article  CAS  PubMed  Google Scholar 

  42. Perucho, M. et al. Cell 27, 467–476 (1981).

    Article  CAS  PubMed  Google Scholar 

  43. Lane, M.-A., Sainten, A. & Cooper, G. M. Proc. natn. Acad. Sci. U.S.A. 78, 5185–5189 (1981).

    Article  ADS  CAS  Google Scholar 

  44. Lane, M. A., Sainten, A. & Cooper, G. M. Cell 28, 873–880 (1982).

    Article  CAS  PubMed  Google Scholar 

  45. Reddy, E. P., Reynolds, R. K., Santos, E. & Barbacid, M. Nature 300, 149–152 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  46. Taposowsky, E. et al. Nature 300, 762–764 (1982).

    Article  ADS  Google Scholar 

  47. Tabin, C. J. et al. Nature 300, 143–148 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  48. Margison, G. P. & O'Conner, P. J. in Chemical Carcinogens and DNA Vol. 1 (ed. Grover, P. L.) 111–159 (CRC Press, Boca Raton, Florida, 1979).

    Google Scholar 

  49. Hohn, B. & Murray, K. Proc. natn. Acad. Sci. U.S.A. 74, 3259–3263 (1977).

    Article  ADS  CAS  Google Scholar 

  50. Benton, W. D. & Davis, R. W. Science 196, 180–182 (1977).

    Article  ADS  CAS  PubMed  Google Scholar 

  51. Rigby, P. W. J., Dieckmann, M., Rhodes, C. & Berg, P. J. molec. Biol. 113, 237–251 (1977).

    Article  CAS  PubMed  Google Scholar 

  52. Frischauf, A.-M., Lehrach, H., Poustka, A. & Murray, N. J. molec. Biol. 170, 827–843 (1983).

    Article  CAS  PubMed  Google Scholar 

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Cooper, C., Park, M., Blair, D. et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 311, 29–33 (1984). https://doi.org/10.1038/311029a0

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