Abstract
The genomic structure of the joining (J) and constant (C) regions of the locus encoding the β-chain of the murine T-cell receptor has been analysed. The gene segments are arranged tandemly (J–C/J–C) within a 15-kilobase region. The two constant-region genes are almost identical, differing by only four amino acids, all in carboxy-terminal portions. Each C region comprises four exons encoding an external globular domain, a small hinge-like region, a transmembrane region and a cytoplasmic tail plus 3′-untranslated region. The two clusters of J regions each contain 7 distinct elements, 12 of which may be functional.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Zinkernagel, R. M. & Doherty, P.C. Adv. Immun. 27, 52–177 (1979).
Sprent, J., Korngold, R. & Molnar-Kimber, K. Springer Semin. Immunopath. 3, 213–245 (1980).
Kappler, J. W., Skidmore, B., White, J. & Marrack, P. J. exp. Med. 153, 1198–1214 (1981).
Hunig, T. R. & Bevan, M. J. J. exp. Med. 155, 111–125 (1982).
Heber-Katz, E. et al. J. exp. Med. 155, 1086–1099 (1982).
Haskins, K. et al. J. exp. Med. 157, 1149–1169 (1983).
Samelson, L. E., Germain, R. N. & Schwartz, R. H. Proc. natn. Acad. Sci. U.S.A. 80, 6972–6976 (1983).
Allison, J. P., MacIntyre, B. W. & Block, D. J. Immun. 129, 2293–2300 (1982).
Meuer, S. et al. J. exp. Med. 157, 705–719 (1983).
McIntyre, B. W. & Allison, J. P. Cell 34, 739–746 (1983).
Kappler, J. W. et al. Cell 35, 295–302 (1983).
Hedrick, S. M., Cohen, D. I., Nielsen, E. A. & Davis, M. M. Nature 308, 149–153 (1984).
Hedrick, S. M., Nielsen, E. A., Kavaler, J., Cohen, D. I. & Davis, M. M. Nature 308, 153–158 (1984).
Honjo, T. A. Rev. Immun. 1, 499–528 (1983).
Chien, Y., Gascoigne, N. R. J., Kavaler, J., Lee, N. E. & Davis, M. M. Nature 309, 322–326 (1984).
Lee, N. E. et al. J. exp. Med. (in the press).
Sakano, H., Huppi, K., Heinrich, G. & Tonegawa, S. Nature 280, 288–294 (1979).
Tonegawa, S. et al. Cold Spring Harb. Symp. quant. Biol. 45, 839–858 (1980).
Kabat, E. A., Wu, T. T., Bilofsky, H., Reid-Miller, M. & Perry, H. Sequences of Proteins of Immunological Interest (U.S. Dept of Health and Human Services, Washington DC, 1983).
Zimmer, E. A. thesis, Univ. California, Berkeley (1981).
Ollo, R. & Rougeon, F. Cell 32, 515–523 (1983).
Yanagi, Y. et al. Nature 308, 145–149 (1984).
Honjo, T. et al. Cell 18, 559–568 (1979).
Oi, V.T. et al. Nature 307, 136–140 (1984).
Komaromy, M. et al. Nucleic Acids Res. 11, 6775–6785 (1983).
Manning, M. J. & Turner, R. J. Comparative Immunobiology (Wiley, New York,1976).
Viera, J. & Messing, J. Gene 19, 259–268 (1982).
Maxam, A. & Messing, J. Meth. Enzym. 65, 499–560 (1980).
Acuto, O. et al. Proc. natn. Acad. Sci. U.S.A. 81, 3851–3855 (1984).
Kavater, J., Davis, M. M. & Chien, Yueh-hsiu Nature 310, 421–423 (1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gascoigne, N., Chien, Yh., Becker, D. et al. Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes. Nature 310, 387–391 (1984). https://doi.org/10.1038/310387a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/310387a0
This article is cited by
-
Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire
Nature Communications (2019)
-
Lack of prominent peptide–major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations
Nature Immunology (2005)
-
Induction of Neonatal Tolerance to Oxidized Lipoprotein Reduces Atherosclerosis In ApoE Knockout Mice
Molecular Medicine (2000)
-
Isolation and sequence analysis of cDNA for the dog T-cell receptor Tcr? and Tcr? chains
Immunogenetics (1993)
-
Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics
Nature (1992)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
