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Glycoprotein C of herpes simplex virus 1 acts as a receptor for the C3b complement component on infected cells

Nature volume 309, pages 633–635 (1984)Cite this article

Abstract

Receptors for the Fc portion of immunoglobulins or for the third component of complement (C3) are present on a variety of circulating and fixed tissue cells including granulocytes, monocytes, lymphocytes and glomerular epithelial cells1–4. Cells which lack Fc receptors may express them after infection by herpes simplex virus (HSV)-1, HSV-2, cytomegalovirus or varicella zoster virus5–8. We recently reported that infection by HSV-1 induces both Fc and C3 receptors on human endothelial cells9. Glycoprotein E of HSV-1 has been shown to function as an Fc receptor10. We now demonstrate that glycoprotein C (gC) of HSV-1 functions as a C3b receptor. This receptor appears following HSV-1, but not HSV-2, infection. Detection of the C3b receptor is blocked by monoclonal antibodies to glycoprotein C (gC) of HSV-1, but not by monoclonal antibodies to other HSV-1 glycoproteins. In addition, the MP mutant of HSV-1, which lacks gC, fails to express a C3b receptor. These results assign a new function of gC of HSV-1 and demonstrate potentially important differences between HSV-1 and HSV-2 glycoproteins.

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Authors and Affiliations

  1. The Joseph Stokes Jr Research Institute, The Children's Hospital of Philadelphia, 34th Street, Philadelphia, Pennsylvania, 19104, USA

    Harvey M. Friedman & Cynthia A. Seidel

  2. School of Dentistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    Gary H. Cohen

  3. School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    Roselyn J. Eisenberg

  4. Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    Douglas B. Cines

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  1. Harvey M. Friedman
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  2. Gary H. Cohen
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  4. Cynthia A. Seidel
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  5. Douglas B. Cines
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Friedman, H., Cohen, G., Eisenberg, R. et al. Glycoprotein C of herpes simplex virus 1 acts as a receptor for the C3b complement component on infected cells. Nature 309, 633–635 (1984). https://doi.org/10.1038/309633a0

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