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A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

Nature volume 308, pages 145–149 (1984)Cite this article

Abstract

We have cloned and sequenced a human mRNA specific for mammalian T-lymphoid cells. The message was found to be expressed in human and murine T lymphoblasts, thymocytes and phytohaemagglutinin-stimulated T lymphocytes. The protein deduced from the cDNA sequence has a molecular weight of 34,938 and shows extensive similarity to the entire length of the variable, joining and constant regions of mammalian immunoglobulin light chains. In addition, the relative positions of the cysteine residues are similar to those of the light chains of murine and human immunoglobulin molecules. These properties suggest that the cDNA clone may correspond to a message that specifies part of the human T-cell receptor.

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Authors and Affiliations

  1. The Ontario Cancer Institute, and Department of Medical Biophysics, University of Toronto, 500 Sherbourne Street, Toronto, Ontario, Canada, M4X 1K9

    Yusuke Yanagi, Yasunobu Yoshikai, Kathleen Leggett, Stephen P. Clark, Ingrid Aleksander & Tak W. Mak

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  1. Yusuke Yanagi
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  2. Yasunobu Yoshikai
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  3. Kathleen Leggett
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  4. Stephen P. Clark
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  5. Ingrid Aleksander
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  6. Tak W. Mak
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Yanagi, Y., Yoshikai, Y., Leggett, K. et al. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature 308, 145–149 (1984). https://doi.org/10.1038/308145a0

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