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Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement

Nature volume 306, pages 243–246 (1983)Cite this article

Abstract

Switching of an Abelson virus-transformed mouse lymphoid cell line from immunoglobulin μ to γ2b heavy-chain synthesis in vitro is accompanied by loss of DNA sequences between the JH and Cγ2b gene segments, and thus cannot be explained by differential RNA processing. The light-chain loci of both μ- and γ2b-producing cell clones are in the embryonic configuration, which indicates that class switching can occur in pre-B cells.

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Authors and Affiliations

  1. Friedrich-Miescher-Laboratorium der Max-Planck-Gesellschaft, Spemannstrasse 37–39, D-7400, Tübingen, FRG

    Peter D. Burrows, Gabriele B. Beck-Engeser & Matthias R. Wabl

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  1. Peter D. Burrows
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  2. Gabriele B. Beck-Engeser
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  3. Matthias R. Wabl
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Burrows, P., Beck-Engeser, G. & Wabl, M. Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement. Nature 306, 243–246 (1983). https://doi.org/10.1038/306243a0

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