Abstract
The potential for a DNA molecule to assume different tertiary structures has been suggested as a possible determinant of transcriptional regulation in eukaryotes1,2. Such forms include cruciforms3,4 transitions from B to Z DNA in the same molecule2,5 and short unpaired stretches of DNA in an alternating copolymer6. All such structures contain regions which are preferentially sensitive to S1 nuclease4–6. We report here an additional class of S1 nuclease sensitive sites associated with short direct repeats of DNA found in the 5′ flanking regions of certain Drosophila melanogaster heat shock genes.
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Mace, H., Pelham, H. & Travers, A. Association of an S1 nuclease-sensitive structure with short direct repeats 5′ of Drosophila heat shock genes. Nature 304, 555–557 (1983). https://doi.org/10.1038/304555a0
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DOI: https://doi.org/10.1038/304555a0
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