Abstract
Analysis of the organization and nucleotide sequence of two human loci related to the transforming gene of Kirsten murine sarcoma virus establishes one as a functional gene and the other as a processed pseudogene. The two final coding exons of the functional gene seem to have arisen by duplication. Differentially spliced mRNAs incorporating one or other of the duplicated exons probably served as the intermediates by which the viral transforming gene and the pseudogene were generated. This suggests that the functional gene may specify either of two related polypeptides depending on the pattern of RNA splicing.
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References
Cooper, G. M. Science 218, 801–806 (1982).
Krontiris, T. G. & Cooper, G. M. Proc. natn. Acad. Sci. U.S.A. 78, 1181–1184 (1981).
Murray, M. J. et al. Cell 25, 355–361 (1981).
Perucho, M. et al. Cell 27, 467–476 (1981).
Shimizu, K., Goldfarb, M., Perucho, M. & Wigler, M. Proc. natn. Acad. Sci. U.S.A. 80, 383–387 (1983).
Pulciani, S. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2845–2849 (1982).
Pulciani, S. et al. Nature 300, 539–542 (1982).
Der, C. J., Krontiris, T. G. & Cooper, G. M. Proc. natn. Acad. Sci. U.S.A. 79, 3637–3640 (1982).
Parada, L. F., Tabin, C. J., Shih, C. & Weinberg, R. A. Nature 297, 474–478 (1982).
Santos, E., Tronick, S. R., Aaronson, S. A., Pulsiani, S. & Barbacid, M. Nature 298, 343–347 (1982).
Lane, M-A., Sainten, A. & Cooper, G. M. Cell 28, 873–880 (1982).
Ellis, R. W. et al. Nature 292, 506–511 (1981).
Papageorge, A., Lowy, D. & Scolnick, E. M. J. Virol. 44, 509–519 (1982).
Shimizu, K. et al. Proc. natn. Acad. Sci. U.S.A. 80, 2112–2116 (1983).
Chang, E. H., Gonda, M. A., Ellis, R. W., Scolnick, E. M. & Lowy, D. R. Proc. natn. Acad. Sci. U.S.A. 79, 4848–4852 (1982).
Tabin, C. J. et al. Nature 300, 143–149 (1982).
Reddy, E. P., Reynolds, R. K., Santos, E. & Barbacid, M. Nature 300, 149–152 (1982).
Taparowsky, E. et al. Nature 300, 762–765 (1982).
Capon, D. J., Chen, E. Y., Levinson, A. D., Seeburg, P. H. & Goeddel, D. V. Nature 302, 33–37 (1983).
McCoy, M. S. et al. Nature 302, 79–81 (1983).
DeFeo, D. et al. Proc. natn. Acad. Sci. U.S.A. 78, 3328–3332 (1981).
O'Brien, S. J., Nash, W. G., Goodwin, J. L., Lowy, D. R. & Chang, E. H. Nature 302, 839–842 (1983).
Jelinek, W. R. et al. Proc. natn. Acad. Sci. U.S.A. 77, 1398–1402 (1980).
Tsuchida, N., Ryder, T. & Ohtsubo, E. Science 217, 937–939 (1982).
Mount, S. M. Nucleic Acids Res. 10, 459–472 (1982).
Hollis, G. F., Hieter, P. A., McBride, O. W., Swan, D. & Leder, P. Nature 296, 321–325 (1982).
Nishioka, Y., Leder, A. & Leder, P. Proc. natn. Acad. Sci U.S.A. 77, 2806–2809 (1980).
Ziff, E. B. Nature 287, 491–499 (1980).
Early, P. et al. Cell 20, 313–319 (1980).
Young, R. A., Hagenbuchle, O. & Schibler, U. Cell 23, 451–458 (1981).
Amara, S. G., Jonas, V., Rosenfeld, M. G., Ong, E. S. & Evans, R. M. Nature 298, 240–244 (1982).
Crabtree, G. R. & Kant, J. A. Cell 31, 159–166 (1982).
King, C. R. & Piatigorsky, J. Cell 32, 707–712 (1983).
Sakaguchi, A. Y. et al. Science 219, 1081–1083 (1983).
Chang, E. H., Furth, M. E., Scolnick, E. M. & Lowy, D. R. Nature 297, 479–483 (1982).
Chen, M.-J., Shimada, T., Mouton, A. D., Harrison, M. & Nienhuis, A. W. Proc. natn. Acad. Sci. U.S.A. 79, 7435–7439 (1982).
Wilde, C. D., Crowther, C. E., Cripe, T. P., Lee, M. G-S. & Cowan, N. J. Nature 297, 83–84 (1982).
Karin, M. & Richards, R. I. Nature 299, 797–802 (1982).
Lemischka, I. & Sharp, P. A. Nature 300, 330–335 (1982).
Capon, D. J. et al. Nature 304, 507–513 (1983).
Benoist, C., O'Hare, K., Breathnach, R. & Chambon, P. Nucleic Acids Res. 8, 127–142 (1980).
Chattopadhyay, S. K. et al. Nature 296, 361–363 (1982).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Maxam, A. & Gilbert, W. Meth. Enzym. 65, 499–559 (1980).
Lawn, R. M., Fritsch, E. F., Parker, R. C., Blake, G. & Maniatis, T. Cell 15, 1157–1174 (1978).
Benton, W. & Davis, R. Science 196, 180–182 (1977).
Taylor, J. M., Illmensee, R. & Summers, S. Biochim. biophys. Acta 442, 324–330 (1976).
Blattner, F. et al. Science 196, 161–169 (1977).
Southern, E. M. J. molec. Biol. 98, 503–517 (1975).
Fogh, J., Fogh, J. M. & Orfeo, T. J. natn. Cancer Inst. 59, 221–226 (1977).
Rimm, D. L., Horness, D., Kucera, J. & Blattner, F. R. Gene 12, 301–309 (1980).
Maniatis, T. et al. Cell 15, 687–701 (1978).
Messing, J., Crea, R. & Seeburg, P. H. Nucleic Acids Res. 9, 301–321 (1981).
Messing, J. & Vieira, J. Gene 19, 269–276 (1982).
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McGrath, J., Capon, D., Smith, D. et al. Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. Nature 304, 501–506 (1983). https://doi.org/10.1038/304501a0
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DOI: https://doi.org/10.1038/304501a0
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