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Effects of altered [ADP-ribose]n metabolism on expression of fetal functions by adult hepatocytes

Nature volume 300, pages 366–368 (1982)Cite this article

Abstract

The nuclear enzyme ADP-ribosyltransferase (ADPRT) catalyses the postsynthetic modification of chromatin proteins1. The significance of [ADP-ribose]n-modified chromatin proteins for the regulation of chromatin function is not understood1. Recently, [ADP-ribose]n biosynthesis has been demonstrated to participate in the repair of some types of DNA damage2–4. Here we demonstrate that another function of [ADP-ribose]n biosynthesis is related to the regulation of the expression of two fetal functions of cultured hepatocytes—the K-type (III) isozyme of pyruvate kinase, and γ-glutamyltranspeptidase, which is also a marker of early neoplastic transformation of liver cells5.

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Author notes

  1. Felix R. Althaus

    Present address: University of Zurich, Institute of Pharmacology and Biochemistry, Winterthurerstrasse 260, CH-8091, Zurich, Switzerland

  2. Yutaka Tsukada: Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan

Authors and Affiliations

  1. McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, Wisconsin, 53706, USA

    Felix R. Althaus, Susan D. Lawrence, Yu-Zhu He, Gerald L. Sattler, Yutaka Tsukada & Henry C. Pitot

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  1. Felix R. Althaus
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  2. Susan D. Lawrence
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  4. Gerald L. Sattler
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  5. Yutaka Tsukada
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  6. Henry C. Pitot
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Althaus, F., Lawrence, S., He, YZ. et al. Effects of altered [ADP-ribose]n metabolism on expression of fetal functions by adult hepatocytes. Nature 300, 366–368 (1982). https://doi.org/10.1038/300366a0

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