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Function recovery following neural transplantation of embryonic septal nuclei in adult rats with septohippocampal lesions

Abstract

The remarkable capacity of transplanted embryonic neurones to innervate the hippocampal formation of mature recipients has been well documented, with the pattern of innervation being shown to be anatomically specific and to resemble normal connectivity1–3. Although transplants are known to have functional consequences in other systems4–9, information has yet to be obtained regarding the functional nature of embryonic septal transplants and the behavioural consequences of transplant innervation of the host hippocampal formation. We provide here evidence that a reinnervation of the hippocampal formation from cholinergic-rich septal transplants is functional in terms of the physiology of neural connectivity and that the newly formed connections can interact with an intrinsic afferent system, the perforant path. Moreover, we demonstrate that the reinnervation can aid in the partial recovery of the performance of a radial maze task that is thought to depend on the integrity of septohippocampal connections10. The behavioural performance of animals with transplants improved significantly compared with those without transplants when both groups were systemically injected with the acetylcholinesterase (AChE) inhibitor, physostigmine. These results suggest that neural transplants from embryonic tissue that reinnervate the hippocampal formation can form functional synaptic connections that can lead to the partial restoration of maze performance.

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References

  1. Björklund, A., Stenevi, U. & Svendgaard, N.-Aa. Nature 262, 787–790 (1976).

    Article  ADS  Google Scholar 

  2. Björklund, A., Segal, M. & Stenevi, U. Brain Res. 170, 409–476 (1979).

    Article  Google Scholar 

  3. Björklund, A. & Stenevi, U. Cell Tissue Res. 185, 289–302 (1977).

    Article  Google Scholar 

  4. Perlow, M. J. et al. Science 204, 643–647 (1979).

    Article  ADS  CAS  Google Scholar 

  5. Björklund, A. & Stenevi, U. Brain Res. 177, 555–560 (1979).

    Article  Google Scholar 

  6. Björklund, A., Dunnett, S. B., Stenevi, U., Lewis, M. E. & Iversen, S. D. Brain Res. 199, 307–334 (1980).

    Article  Google Scholar 

  7. Gash, D. & Sladek, J. R. Jr Peptides 1, 11–14 (1980).

    Article  CAS  Google Scholar 

  8. Freed, W. J. et al. Annls Neurol. 8, 510–519 (1980).

    Article  CAS  Google Scholar 

  9. Björklund, A., Stenevi, U., Dunnett, S. B. & Iversen, S. D. Nature 289, 497–499 (1981).

    Article  ADS  Google Scholar 

  10. Olton, D. S., Walker, J. A. & Gage, F. H. Brain Res. 139, 295–308 (1978).

    Article  CAS  Google Scholar 

  11. Stenevi, U., Björklund, A. & Svendgaard, N.-Aa. Brain Res. 114, 1–20 (1976).

    Article  CAS  Google Scholar 

  12. Whitehouse, L. Psychopharmacology 9, 183–188 (1966).

    Article  CAS  Google Scholar 

  13. Warburton, D. M. & Brown, K. Psychopharmacology 27, 275–284 (1972).

    Article  CAS  Google Scholar 

  14. Roberts, W. A. & Dale, H. I. Learning and Motivation 12, 261–281 (1981).

    Article  Google Scholar 

  15. Dunnett, S. D., Low, W. C., Iversen, S. D., Stenevi, U. & Bjorklund, A. Brain Res. (in the press).

  16. Lømo, T. Expl Brain Res. 12, 18–45 (1971).

    Google Scholar 

  17. Lømo, T. Expl Brain Res. 12, 46–63 (1971).

    Google Scholar 

  18. Hjorth-Simonsen, A. & Jeune, B. J. comp. Neurol. 144, 215–232 (1972).

    Article  CAS  Google Scholar 

  19. Steward, O. J. comp. Neurol. 167, 285–314 (1976).

    Article  CAS  Google Scholar 

  20. Fox, S. E. & Ranck, J. B. Jr Neuroscience 4, 1467–1478 (1979).

    Article  CAS  Google Scholar 

  21. Izquierdo, I. & Vasquez, B. Expl Neurol. 21, 133–146 (1968).

    Article  Google Scholar 

  22. Alvarez-Leefmans, F. J. & Gardner-Medwin, A. R. J. Physiol., Lond. 249, 14P–16P (1975).

    Google Scholar 

  23. Petsch, H., Stumpf, C. & Gogolak, G. Electroenceph. clin. Neurophysiol. 14, 202–211 (1962).

    Article  Google Scholar 

  24. Gogolak, G., Stumpf, C., Petsche, H. & Sterc, J. Brain Res. 7, 201–207 (1968).

    Article  CAS  Google Scholar 

  25. Lund, R. D. & Hauschka, S. D. Science 193, 582–584 (1976).

    Article  ADS  CAS  Google Scholar 

  26. Oblinger, M. M., Hallas, B. H. & Das, G. D. Brain Res. 189, 228–232 (1980).

    Article  CAS  Google Scholar 

  27. Kromer, L. F., Björklund, A. & Stenevi, U. Brain Res. 210, 153–171 (1981).

    Article  CAS  Google Scholar 

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Low, W., Lewis, P., Terri Bunch, S. et al. Function recovery following neural transplantation of embryonic septal nuclei in adult rats with septohippocampal lesions. Nature 300, 260–262 (1982). https://doi.org/10.1038/300260a0

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