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Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer

Nature volume 300, pages 231–237 (1982)Cite this article

Abstract

DNA-mediated gene transfer was used to identify cloned class I genes from the major histocompatibility complex of the BALB/c mouse. Three genes encoding the transplantation antigens H–2 Kd, Dd and Ld were identified as well as genes encoding the Qa-2,3 and two TL differentiation antigens. As many as 10 putative novel class I genes were detected by the association of their gene products with β2-microglobulin. Alloantiserum prepared to one of the novel antigens was used to demonstrate the expression of the previously undetected antigen on spleen cells of various inbred, congeneic, and recombinant congeneic strains of mice.

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Authors and Affiliations

  1. Division of Biology, California Institute of Technology, Pasadena, California, 91125, USA

    Robert S. Goodenow, Beverly Taylor Sher, Kurt Eakle & Leroy Hood

  2. Department of Microbiology, USC Medical School, Los Angeles, California, 90033, USA

    Minnie McMillan

  3. AMGen, Newbury Park, California, 91320, USA

    Margery Nicolson

  4. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, 91125, USA

    Norman Davidson

Authors
  1. Robert S. Goodenow
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  2. Minnie McMillan
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  3. Margery Nicolson
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  4. Beverly Taylor Sher
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  5. Kurt Eakle
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  6. Norman Davidson
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  7. Leroy Hood
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Goodenow, R., McMillan, M., Nicolson, M. et al. Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer. Nature 300, 231–237 (1982). https://doi.org/10.1038/300231a0

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