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Genetic and molecular mechanisms of viral pathogenesis: implications for prevention and treatment

Nature volume 300, pages 19–23 (1982)Cite this article

Abstract

The pathogenesis of infection of mice by the mammalian reoviruses involves several discrete steps. Each of the three viral outer capsid proteins has a highly distinct and specialized role: one protein (σ1) binds to cell surface receptors; a second protein (µ1C) determines the capacity for viral growth at mucosal surfaces; and the third protein (σ3) is responsible for inhibiting cell macromolecular synthesis. A detailed picture of the molecular basis of reovirus virulence and attenuation is now emerging.

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Authors and Affiliations

  1. Departments of Microbiology and Pathology, Harvard Medical School,

    Bernard N. Fields & Mark I. Greene

  2. Department of Medicine (Infectious Disease), Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA

    Bernard N. Fields & Mark I. Greene

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  1. Bernard N. Fields
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  2. Mark I. Greene
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Fields, B., Greene, M. Genetic and molecular mechanisms of viral pathogenesis: implications for prevention and treatment. Nature 300, 19–23 (1982). https://doi.org/10.1038/300019a0

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