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Sequence of an HLA-DR α-chain cDNA clone and intron-exon organization of the corresponding gene

Nature volume 299, pages 750–752 (1982)Cite this article

Abstract

The HLA–DR and related antigens are the major cell-surface glycoproteins identified so far as involved in regulation of the immune response in humans1. Here we present and discuss the sequence of cloned cDNA copies of the mRNA for the HLA–DR α-chain2. The sequence is 1,195 nucleotides long, with one open reading frame encoding a 254 amino acid primary translation product. After cleavage of the signal sequence this yields a mature polypeptide of 229 residues. Four introns have been located within the corresponding genomic sequence revealing a correlation between the protein domain structure and the genomic exon organization. Analysis of the HLA–DR α-chain amino acid sequence shows a clear homology with HLA–ABC, β2-microglobulin and immunoglobulin domains.

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Author notes

  1. Frank Grosveld: National Institute for Medical Research, Mill Hill, London NW7 1AA, UK

Authors and Affiliations

  1. Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK

    Janet S. Lee, John Trowsdale, Paul J. Travers, Janet Carey, Frank Grosveld, John Jenkins & Walter F. Bodmer

Authors
  1. Janet S. Lee
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  2. John Trowsdale
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  3. Paul J. Travers
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  4. Janet Carey
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  5. Frank Grosveld
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  7. Walter F. Bodmer
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Lee, J., Trowsdale, J., Travers, P. et al. Sequence of an HLA-DR α-chain cDNA clone and intron-exon organization of the corresponding gene. Nature 299, 750–752 (1982). https://doi.org/10.1038/299750a0

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