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The evolutionary past of the major histocompatibility complex and the future of cellular immunology

THE penetration of the major histocompatibility complex (MHC) with cloned DNA probes has opened up a new approach to an old evolutionary problem — how to account for the unparalleled polymorphism of the cell-surface antigens it encodes. This spring, representatives of the main laboratories involved met in Oxford* to compare notes, and to discuss their strategies for research on the functions of the MHC products.

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Robertson, M. The evolutionary past of the major histocompatibility complex and the future of cellular immunology. Nature 297, 629–632 (1982). https://doi.org/10.1038/297629a0

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