Abstract
Spontaneous mutations which activate the cryptic bgl operon of Escherichia coli K12 are caused by insertion of DNA at a site, bglR, within the operon. Two insertion elements, IS1 and IS5, have been observed to effect this activation. Once the activating insertion has occurred the operon is inducible by βglucosides in a cyclic AMP-dependent manner.
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Reynolds, A., Felton, J. & Wright, A. Insertion of DNA activates the cryptic bgl operon in E. coli K12. Nature 293, 625–629 (1981). https://doi.org/10.1038/293625a0
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DOI: https://doi.org/10.1038/293625a0
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