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The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes

Nature volume 292, pages 506–511 (1981)Cite this article

Abstract

The Harvey and Kirsten strains of murine sarcoma virus encode enzymatically and serologically related p21 src proteins which are required for virally mediated cellular transformation. The genes in each virus encoding p21 show such extensive divergence from each other that cloned probes from these genes detect distinct sets of cellular genes in the DNA from several vertebrate species. These data suggest that cellular p21 sarc genes constitute a divergent family of vertebrate genes that can regulate the growth of cells.

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Authors and Affiliations

  1. Laboratory of Tumor Virus Genetics, National Cancer Institute, Bethesda, Maryland, 20205, USA

    Ronald W. Ellis, Deborah DeFeo, Thomas Y. Shih & Edward M. Scolnick

  2. Biological Carcinogenesis Program, Frederick Cancer Research Center, Frederick, Maryland, 21701, USA

    Matthew A. Gonda & Howard A. Young

  3. Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania, 19104, USA

    Nobuo Tsuchida

  4. Dermatology Branch, National Cancer Institute, Bethesda, Maryland, 20205, USA

    Douglas R. Lowy

Authors
  1. Ronald W. Ellis
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  2. Deborah DeFeo
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  3. Thomas Y. Shih
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  4. Matthew A. Gonda
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  5. Howard A. Young
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  6. Nobuo Tsuchida
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  7. Douglas R. Lowy
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  8. Edward M. Scolnick
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Ellis, R., DeFeo, D., Shih, T. et al. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature 292, 506–511 (1981). https://doi.org/10.1038/292506a0

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