Abstract
The sequences of four embryonic mouse immunoglobulin VH genes have been compared. All genes end at codon 98 and code for a hydrophobic signal peptide of 19 residues interrupted at codon −4 by an intron of 83 base pairs. Substitutions occur in all gene segments but at a significantly higher frequency in the hypervariable regions. The data suggest an evolutionary basis for the diversity of immunoglobulin genes. Divergence resulted also in a termination codon in two of the genes, suggesting that part of the V gene repertoire cannot be expressed unless some correction mechanism is available.
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Givol, D., Zakut, R., Effron, K. et al. Diversity of germ-line immunoglobulin VH genes. Nature 292, 426–430 (1981). https://doi.org/10.1038/292426a0
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DOI: https://doi.org/10.1038/292426a0
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