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An aminoacyl tRNA synthetase binds to a specific DNA sequence and regulates its gene transcription

Nature volume 291, pages 632–635 (1981)Cite this article

Abstract

Alanine tRNA synthetase represses transcription of its own gene by binding specifically to a palindromic sequence which flanks the gene's transcription start site. Transcription repression is greatly enhanced by elevated concentrations of the cognate amino acid. The amino acid effect is caused by direct association of the ligand with the synthetase, which in turn mediates tighter binding to the DNA.

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Authors and Affiliations

  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Scott D. Putney & Paul Schimmel

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  1. Scott D. Putney
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  2. Paul Schimmel
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Putney, S., Schimmel, P. An aminoacyl tRNA synthetase binds to a specific DNA sequence and regulates its gene transcription. Nature 291, 632–635 (1981). https://doi.org/10.1038/291632a0

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