Abstract
Inducer T lymphocytes activate other cells to divide and express new function. Known target cells include other lymphocytes and haematopoietic stem cells1. We now provide evidence that the inducer T cell acts on another important target population: mast cells. Mast cells have a central role in the expression of immediate hypersensitivity and are also prominent in T-cell mediated reactions of the delayed type2–7. Because the proliferation of differentiated cells is often regulated by soluble growth factors, we examined an inducer T-cell clone for its ability to stimulate mast cell proliferation. We report here that cloned Ly1+2− inducer T cells produce a factor that selectively induces morphologically and karyotypically normal mouse mast cell clones to proliferate. We therefore suggest that inducer T cells may regulate mast cell numbers by releasing a soluble growth factor that stimulates them to divide. Because mast cell products also affect certain T-cell functions8–10, mast cell-T cell interactions may comprise part of an immunoregulatory circuit.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Nabel, G., Greenberger, J. S., Sakakeeny, M. A. & Cantor, H. Proc. natn. Acad. Sci. USA. 78, 1157–1161 (1981).
Dvorak, H. F. et al. Lab. Invest. 31, 111–130 (1974).
Dvorak, A. M., Mihm, M. C. Jr & Dvorak, H. F. Lab. Invest. 34, 179–191 (1976).
Ishizaka, T., Okudaira, H., Mauser, L. E. & Ishizaka, K. J. Immun. 116, 747–754 (1976).
Ginsburg, H., Nir, I., Hammel, I., Eren, R., Weissman, B. A. & Naot, Y. Immunology 35, 485–502 (1978).
Galli, S. J. & Dvorak, H. F. in Cellular, Molecular, and Clinical Aspects of Allergic Disorders (eds Gupta, S. & Good, R. A.) 1–53 (Plenum, New York, 1979).
Askenase, P. W. Springer Semin. Immunopath. 2, 417–442 (1980).
Schwartz, E., Sutton, S., Askenase, P. W. & Gershon, R. K. Immunopharmacology 2, 179 (1980).
Rocklin, R. E. J. clin. Invest. 57, 1051–1058 (1976).
Plaut, M., Lichtenstein, L. M., Gillespie, E. & Henney, C. S. J. Immun. 111, 389–394 (1973).
Burnet, F. M. J. Path. Bact. 89, 271–284 (1965).
Burnet, F. M. Cell. Immun. 30, 358–360 (1977).
Nabel, G., Fresno, M., Chessman, A. & Cantor, H. Cell 23, 19–28 (1981).
Scheid, M. P. & Triglia, D. Immunogenetics 9, 423–433 (1979).
Silverstone, A. E. et al. in Differentiation of Normal and Neoplastic Hematopoietic Cells (eds Clarkson, B., Marks, P. & Till, J.) 433–453 (Cold Spring Harbor Laboratory, New York, (1978).
Galli, S. J., Galli, A. S., Dvorak, A. M. & Dvorak, H. F. J. Immun. 117, 1085–1092 (1976).
Dvorak, A. M., Hammond, M. E., Dvorak, H. F. & Karnovsky, M. J. Lab. Invest. 27, 561–574 (1972).
Nabel, G. et al. (in preparation).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nabel, G., Galli, S., Dvorak, A. et al. Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells. Nature 291, 332–334 (1981). https://doi.org/10.1038/291332a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/291332a0
This article is cited by
-
Mast cells and IgE in defense against lethality of venoms: Possible "benefit" of allergy*
Allergo Journal (2020)
-
Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy
Allergo Journal International (2020)
-
Stat4 suppresses the proliferation of connective tissue-type mast cells
Laboratory Investigation (2008)
-
Distinct role for c-kit receptor tyrosine kinase and SgIGSF adhesion molecule in attachment of mast cells to fibroblasts
Laboratory Investigation (2005)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
