Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Nonrandom segregation of nucleolar organizing chromosomes at mitosis?

Abstract

The random assortment of non-homologous chromosomes at meiosis is one of the fundamental tenets of genetics, to which few exceptions have been documented1. The segregation of mitotic chromatids is believed to be similarly random. We report here that we seem to have discovered a new exception to this rule, in that nucleolar organizing chromosomes remain associated with one another, held in the same lateral orientation, for several mitotic cycles.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Sybenga, J. General Cytogenetics, 310–314 (North-Holland, Amsterdam, 1972).

    Google Scholar 

  2. Busch, H. & Smetana, K. The Nucleolus (Academic, New York, 1970).

    Google Scholar 

  3. Ferguson-Smith, M. A. & Handmaker, S. D. Lancet i, 638 (1961).

    Article  Google Scholar 

  4. Henderson, A. S., Warburton, D. & Atwood, K. C. Nature 245, 95 (1973).

    Article  ADS  CAS  Google Scholar 

  5. Latt, S. A. Proc. natn. Acad. Sci. U.S.A. 70, 3395 (1973).

    Article  ADS  CAS  Google Scholar 

  6. Perry, P. & Wolff, S. Nature 251, 156 (1974).

    Article  ADS  CAS  Google Scholar 

  7. du Praw, E. J. DNA and Chromosomes (Holt, Rinehart & Winston, New York, 1970).

    Google Scholar 

  8. White, M. J. D. The Chromosomes, 14–15 (Chapman & Hall, London, 1973).

    Google Scholar 

  9. Sele, B. et al. Hum. Genet. 39, 39 (1977).

    Article  CAS  Google Scholar 

  10. Hansson, A. Hereditas 90, 59 (1979).

    Article  CAS  Google Scholar 

  11. Taysi, K. Clin. Genet. 8, 319 (1975).

    Article  CAS  Google Scholar 

  12. Cooke, P. & Curtis, D. J. Hum. Genet. 23, 279 (1974).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bobrow, M., Heritage, J. Nonrandom segregation of nucleolar organizing chromosomes at mitosis?. Nature 288, 79–81 (1980). https://doi.org/10.1038/288079a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/288079a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing