Abstract
Calmodulin, a protein that binds calcium with high affinity and specificity, is structurally conserved and functionally preserved throughout the animal and plant kingdoms. It serves as an intracellular Ca2+-receptor and mediates the Ca2+ regulation of cyclic nucleotide and glycogen metabolism, secretion, motility and Ca2+ transport. Calmodulin is also a dynamic component of the mitotic apparatus.
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References
Rasmussen, H., Goodman, D. B. P., Freidmann, N., Allen, J. A. & Kurokawa, K. in Handbook of Physiology, Endocrinology, Section VII (ed. Aurbach, G. D.) 225–264 (Williams and Wilkins, Baltimore, 1976).
Rubin, R. P. Calcium and the Secretory Process (Plenum, New York, 1974).
Dedman, J. R., Brinkley, B. R. & Means, A. R. Adv. Cyclic Nucleotide Res. 11, 131–174 (1979).
Meyer, W. L., Fischer, W. H. & Krebs, E. G. Biochemistry 3, 1033–1039 (1964).
Bradham, L. S., Holt, D. A. & Samo, M. Biochim. biophys. Acta 201, 250–160 (1969).
Kakiuchi, S., Yamazaki, R. & Nakajima, H. Proc. Jap. Acad. 46, 587–591 (1970).
Cheung, W. Y. Biochem. biophys. Res. Commun. 33, 533–538 (1970).
Wolff, D. J. & Siegel, F. J. biol. Chem. 247, 4180–4185 (1972).
Weisenberg, R. C. Science 177, 1104–1105 (1972).
Bond, G. H. & Clough, D. L. Biochim. biophys. Acta 232, 592–599 (1973).
Pires, E., Perry, S. V. & Thomas, M. A. W. FEBS Lett. 41, 292–296 (1974).
Dedman, J. R., Potter, J. D., Jackson, R. L., Johnson, J. D. & Means, A. R. J. biol. Chem. 252, 8415–8522 (1977).
Dedman, J.R., Jackson, R.L., Schreiber, W.E. & Means, A.R. J. biol. Chem. 253, 343–346 (1977).
Vanaman, T. C., Sharief, F. & Watterson, D. M. in Calcium-Binding Proteins & Calcium Function (eds Wasserman, R. H. et al.) 106–116 (North-Holland, New York, 1977).
Vanaman, T. C. & Sharief, F. Fedn Proc. 38, 788 (1979).
Jackson, R. L. et al. Biochem. biophys. Res. Commun. 77, 723–729 (1977).
Uy, R. & Wold, F. Science 198, 890–896 (1977).
Yerna, M. J., Hartshorne, D. J. & Goldman, R. D. Biochemistry 18, 673–678 (1979).
Amphlett, G., Vanaman, T. & Perry, S. FEBS Lett. 72, 163–168 (1976).
Dedman, J. R., Potter, J. D. & Means, A. R. J. biol. Chem. 252, 2537–2440 (1977).
Cohen, P., Picton, C. & Klee, C. B. FEBS Lett. 104, 25–30 (1979).
Kuo, I. C. Y. & Coffee, C. J. J. biol. Chem. 251, 1603–1609 (1976).
Van Eerd, J.-P. & Takahashi, K. Biochemistry 15, 1171–1180 (1976).
Collins, J. H., Greaser, M. L., Potter, J. D. & Horn, M. J. J. biol. Chem. 252, 6356–6362 (1977).
Kretsinger, R. H. & Nockolds, C. E. J. biol. Chem. 248, 3313–3326 (1973).
Dedman, J. R., Welsh, M. J. & Means, A. R. J. biol. Chem. 253, 7515–7521 (1978).
Chafouleas, J. G., Dedman, J. R., Munjaal, R. P. & Means, A. R. J. biol. Chem. 254, 10262–10267 (1979).
Andersen, B., Osborn, M. & Weber, K. Cytobiologie 17, 354–364 (1978).
Wallace, R. W. & Cheung, W. Y. J. biol. Chem. 254, 6564–6571 (1979).
Watterson, D. M., van Eldik, J. J., Smith, R. E. & Vanaman, T. C. Proc. natn. Acad. Sci. U.S.A. 73, 2711–2715 (1976).
LaPorte, D. C., Gidwitz, S., Wever, M. J. & Storm, D. R. Biochem. biophys. Res. Commun. 86, 1169–1177 (1979).
Beale, E. G., Dedman, J. R. & Means, A. R. Endocrinology 101, 1621–1634 (1977).
Means, A. R., Fakunding, J. L., Huckins, C., Tindall, D. J. & Vitale, R. Rec. Prog. Horm. Res. 32, 477–527 (1976).
Fuller, G. M., Brinkley, B. R. & Boughter, J. M. Science 187, 948–950 (1975).
Welsh, M. J., Dedman, J. R., Brinkley, B. R. & Means, A. R. Proc. natn. Acad. Sci. U.S.A. 75, 1867–1871 (1978).
Yazawa, M. & Yagi, K. J. Biochem. 82, 287–289 (1977).
Yagi, K., Yazawa, M., Kakiuchi, S., Ohshima, M. & Uenishi, K. J. biol. Chem. 253, 1338–1340 (1978).
Waisman, D., Stevens, F. & Wang, J. J. biol. Chem. 253, 1106–1113 (1977).
Dabrowska, R. & Hartshorne, D. J. Biochem. biophys. Res. Commun. 85, 1352–1359 (1978).
Hathaway, D. R. & Adelstein, R. S. Proc. natn. Acad. Sci. U.S.A. 76, 1653–1657 (1979).
Welsh, M. J., Dedman, J. R., Brinkley, B. R. & Means, A. R. J. Cell Biol. 81, 624–634 (1979).
Brinkley, B. R. & Cartwright, J. Ann. N.Y. Acad. Sci. 253, 428–439 (1975).
Brinkley, B. R. & Cartwright, J. J. Cell Biol. 50, 416–431 (1971).
Olmstead, J. B. & Borisy, G. G. Biochemistry 14, 2996–3005 (1975).
Borisy, G. G., Marcum, J. M., Olmstead, J. B., Murphy, D. B. & Johnson, K. A. Ann. N.Y. Acad. Sci. 253, 107–132 (1975).
Perrin, D. D. & Sayce, I. G. Talanta 14, 833–842 (1967).
Potter, J. D. & Gergely, J. J. biol. Chem. 250, 4628–4633 (1975).
Marcum, J. M., Dedman, J. R., Brinkley, B. R. & Means, A. R. Proc. natn. Acad. Sci. U.S.A. 75, 3771–3775 (1978).
Kumagai, H. & Nishida, E. J. Biochem. 85, 1267–1274 (1979).
Brinkley, B. R., Fuller, G. M. & Highfield, D. P. in Cell Motility (eds Goldman, R., Pollard, T. & Rosenbaum, J.) 435–456 (Cold Spring Harbor Laboratory, New York, 1976).
Herman, I. M. & Pollard, T. D. J. Cell Biol. 80, 509–520 (1979).
Dabrowska, R., Aromatorio, D., Sherry, J. M. F. & Hartshorne, D. J. Biochemistry 17, 253–258 (1978).
Hinds, T. R., Larsen, F. L. & Vincenzi, F. F. Biochem. biophys. Res. Commun. 81, 455–461 (1978).
LePeuch, C. J., Haiech, J. & Demaille, J. G. Biochemistry 18, 5150–5157 (1979).
Lin, C. T., Dedman, J. R., Brinkley, B. R. & Means, A. R. J. Cell Biol. (in the press).
Iqbal, Z. & Ochs, S. J. Neurochemistry 31, 409–418 (1978).
Grab, D. J., Berzins, K., Cohen, R. S. & Siekevitz, P. J. biol. Chem. 254, 8690–8696 (1979).
Wood, J. G., Wallace, R. W., Whitaker, J. N. & Cheung, W. Y. J. Cell Biol. 84, 66–76 (1980).
DeLorenzo, R. J., Freedman, S. D., Yohe, W. B. & Maurer, S. C. Proc. natn. Acad. Sci. U.S.A. 76, 1838–1842 (1979).
Jamieson, G. A. Jr, Vanaman, T. C. & Blum, J. J. Proc. natn. Acad. Sci. U.S.A. 76, 6471–6475 (1979).
Lenz, R. W., Jones, H. P., Palevitz, B. A. & Cormier, M. J. Proc. natn. Acad. Sci. U.S.A. (in the press).
Voglmayr, J. K., Quinn, P.J. & White, I. G. Biol. Reprod. 1, 215–222 (1969).
Linden, C. D., Dedman, J. R., Chafouleas, J. G., Means, A. R. & Roth, T. F. Proc. natn. Acad. Sci. U.S.A. (in the press).
Grand, R. J. & Perry, S. V. Biochem. J. 183, 285–295 (1979).
Klee, C. B., Crouch, T. H. & Krinks, M. H. Biochemistry 18, 722–729 (1979).
Kincaid, R. L. & Vaughan, M. Proc. natn. Acad. Sci. U.S.A. 76, 4903–4907 (1979).
Cohen, P. et al. FEBS Lett. 92, 287–293 (1978).
Haaker, H. & Racker, E. J. biol. Chem. 254, 6598–6602 (1979).
Niggli, V., Penniston, J. T. & Carafoli, E. J. biol. Chem. 254, 9955–9958 (1979).
Westcott, K. R., LaPorte, D. C. & Storm, D. R. Proc. natn. Acad. Sci. U.S.A. 76, 204–208 (1979).
Bromstrom, C. O., Huang, Y. C., Breckenridge, B. N. & Wolff, D. J. Proc. natn. Acad. Sci. U.S.A. 72, 64–68 (1975).
Schulman, H. & Greengard, P. Nature 271, 478–479 (1978).
Schulman, H. & Greengard, P. Proc. natn. Acad. Sci. U.S.A. 75, 5432–5436 (1978).
Yamauchi, T. & Fujisawa, H. Biochem. biophys. Res. Commun. 90, 1172–1178 (1979).
Soderling, T. R., Srivastava, A. K., Bass, M. A. & Khatra, B. S. Proc. natn. Acad. Sci. U.S.A. 76, 2536–2540 (1970).
DePaoli-Roach, A. A., Roach, P. J. & Lamer, J. J. biol. Chem. 254, 4212–4219 (1979).
Walsh, K. X., Millikin, D. M., Schlender, K. K. & Reimann, E. M. J. biol. Chem. 254, 6611–6616 (1979).
Gopinath, R. M. & Vincenzi, F. F. Biochem. biophys. Res. Commun. 77, 1203–1209 (1977).
Jarrett, H. W. & Penniston, J. T. Biochem. biophys. Res. Commun. 77, 1210–1216 (1977).
Sobue, K., Ichida, S., Yoshida, H., Yamazaki, R. & Kakoicjo, S. FEBS Lett. 99, 199–202 (1979).
Ilundian, A. & Naftalin, R. J. Nature 279, 466–468 (1979).
Anderson, J. M. & Cormier, M. J. Biochem. biophys. Res. Commun. 84, 595–602 (1978).
Yamauchi, T. & Fujisawa, H. Biochem. biophys. Res. Commun. 90, 28–35 (1979).
Wong, P. Y. K. & Cheung, W. Y. Biochem. biophys. Res. Commun. 90, 473–480 (1979).
Brinkley, B. R. et al. 37th Ann. Proc. Electron Microscopy Soc. Am. 14–17 (1979).
Lin, T. et al. J. Histochem. Cytochem. 23, 624–630 (1975).
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Means, A., Dedman, J. Calmodulin—an intracellular calcium receptor. Nature 285, 73–77 (1980). https://doi.org/10.1038/285073a0
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DOI: https://doi.org/10.1038/285073a0
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