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T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

Nature volume 281, pages 456–461 (1979)Cite this article

Abstract

A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of California, San Francisco, California, 94143

    Leroy F. Liu, Chung-Cheng Liu & Bruce M. Alberts

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  1. Leroy F. Liu
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  2. Chung-Cheng Liu
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  3. Bruce M. Alberts
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Liu, L., Liu, CC. & Alberts, B. T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication. Nature 281, 456–461 (1979). https://doi.org/10.1038/281456a0

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