Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

HLA and testicular cancer

Abstract

HLA IS involved not only in transplantation, but is also associated with many disease states. This first became evident when the major histocompatibility complex of the mouse (H–2) was shown to play a major part in determining resistance to Gross leukaemia virus1. Subsequent studies in both animals and man have shown that many disease states are associated with, and perhaps regulated by, the major histocompatibility complex2,3. We now present the tissue typing results from a group of patients with testicular cancer. The results show an abnormally high antigen frequency for HLA-Dw7 in patients with testicular teratocarcinoma.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Lilly, F., Boyse, E. A. & Old, L. J. Lancet ii, 1207–1209 (1964).

    Article  Google Scholar 

  2. Dausset, J. & Svejgaard, A. (eds) HLA and Disease (Munksgaard, Copenhagen, 1977).

  3. McDevitt, H. O. & Bodmer, W. F. Lancet i, 1269–1275 (1974).

    Article  Google Scholar 

  4. O'Leary, J., Reinsmoen, N. & Yunis, E. J. in Manual of Clinical Immunology (eds Rose, N. & Friedman, H.) 821–832 (Am. Soc. Microbiol., Washington, 1976).

    Google Scholar 

  5. Cannady, W. G., DeWolf, W. C., Williams, R. M. & Yunis, E. J. Prog. clin. Pathol. 7, 239–265 (1978).

    CAS  PubMed  Google Scholar 

  6. Svejgaard, A. in Manual of Clinical Immunology (eds Rose, N. & Friedman, H.) 841–850 (Am. Soc. Microbiol., Washington, 1976).

    Google Scholar 

  7. Miller, L. H., Mason, S. J., Dvorak, J. A., McGinniss, M. H. & Rothman, I. K. Science 189, 561–563 (1975).

    Article  ADS  CAS  Google Scholar 

  8. Ochs, H. D. et al. New Engl. J. Med. 296, 470–475 (1977).

    Article  CAS  Google Scholar 

  9. Lapes, M. Iozzi, L., Ziegenfus, W., Antoniades, K. & Vivagua, R. Cancer 39, 2317–2320 (1977).

    Article  CAS  Google Scholar 

  10. Artzt, K. & Bennett, D. Nature 256, 545–547 (1975).

    Article  ADS  CAS  Google Scholar 

  11. Klein, J. & Hammerberg, C. Immun. Rev. 33, 70–104 (1977).

    Article  CAS  Google Scholar 

  12. Bennett, D. Cell 6, 441–454 (1975).

    Article  Google Scholar 

  13. Jacob, F. Immun. Rev. 33, 3–32 (1977).

    Article  CAS  Google Scholar 

  14. Artzt, K., Bennett, D., Boyse, E. A. & Jacob, F. Proc. natn. Acad. Sci. U.S.A. 70, 2988–2993 (1973).

    Article  ADS  CAS  Google Scholar 

  15. Vitetta, E., Artzt, K., Bennett, D., Boyse, E. A. & Jacob, G. Proc. natn. Acad. Sci. U.S.A. 72, 3215–3219 (1975).

    Article  ADS  CAS  Google Scholar 

  16. Amos, D. B., Johnson, A. H., Ruderman, R. J., Mendell, N. & Yunis, E. J. New Concepts in Transplantation Immunity (ed., Canley, R.) (M. D. Anderson Symposium, University of Texas, Houston, 1975).

    Google Scholar 

  17. Buc-Caron, M., Gachelin, G., Hofnung, M. & Jacob, F. Proc. natn. Acad. Sci. U.S.A. 71, 1730–1734 (1974).

    Article  ADS  CAS  Google Scholar 

  18. Hogan, B., Fellous, M., Avner, P. & Jacob, F. Nature 270, 515–517 (1977).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

DEWOLF, W., EINARSON, M., YUNIS, E. et al. HLA and testicular cancer. Nature 277, 216–217 (1979). https://doi.org/10.1038/277216a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/277216a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing