Abstract
ANTIBODIES directed against prostaglandin–albumin conjugates have been used previously as prostaglandin antagonists. Horton and Poyser1 have demonstrated that the oestrus cycle in the guinea pig is prolonged in animals immunised against prostaglandin F2α (PGF2α). Ferreira et al.2 demonstrated that rats containing antibodies to E-type prostaglandins develop a significantly reduced inflammatory oedema in response to carageenin compared with control animals. We report here that antibodies can be used to antagonise the effects of prostacyclin both in vitro and in vivo.
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References
- 1.
Horton, E. W. & Poyser, N. L. Prostaglandins 5, 349–355 (1974).
- 2.
Ferreira, S. H., Flower, R. J., Parsons, M. F. & Vane, J. R. Prostaglandins 8, 433–437 (1974).
- 3.
Moncada, S., Gryglewski, R., Bunting, S. & Vane, J. R. Nature 263, 663–665 (1976).
- 4.
Gryglewski, R., Bunting, S., Moncada, S., Flower, R. J. & Vane, J. R. Prostaglandins 12, 685–713 (1976).
- 5.
Armstrong, J. M. et al. Br. J. Pharmac. 61, 136P (1977).
- 6.
Fitzpatrick, T. M. et al. Circulation Res. 42, 192–194 (1978).
- 7.
Lefer, A. M. et al. Science 200, 52–54 (1978).
- 8.
Weksler, B. B., Marcus, A. J. & Jaffe, E. A. Proc. natn. Acad. Sci. U.S.A. 74, 3922–3926 (1977).
- 9.
Harker, L. A., Joy, N., Wall, R. T., Quadracci, L. & Striker, G. Thromb. Haemostas. 38, 137 (1977).
- 10.
MacIntyre, D. E., Pearson, J. D. & Gordon, J. L. Nature 271, 549–551 (1978).
- 11.
DeDeckere, E. A. M., Nugteren, D. H. & Ten Hoor, F. Nature 268, 160–163 (1977).
- 12.
Pace-Asciak, C. Experientia 32, 291–292 (1976).
- 13.
Wen-Chang, C. & Murota, S. Biochim. biophys. Acta 468, 136–144 (1977).
- 14.
Johnson, R. A. et al. Prostaglandins 12, 915–918 (1976).
- 15.
Nicolaou, K. C., Barnette, W. E., Gasic, G. P., Magolda, R. L. & Sipio, W. J. J. Chem. Soc. chem. Commun. 630–631 (1977).
- 16.
Caldwell, B. V. et al. J. reprod. Med. 9, 361–371 (1972).
- 17.
Nicolaou, K. C., Barnette, W. E., Gasic, G. P. & Magolda, R. L. J. Am. chem. Soc. 99, 7736–7738 (1977).
- 18.
Siegl, A. M. et al. Fedn Proc. 37, 256 (1978).
- 19.
Pong, S. & Levine, L. in The Prostaglandins 3 (ed. Ramwell, P. W.) 43 (Plenum, New York, 1977).
- 20.
Gorman, R. R., Bunting, S. & Miller, O. V. Prostaglandins 13, 377–388 (1977).
- 21.
Tateson, J. E., Moncada, S. & Vane, J. R. Prostaglandins 13, 389–397 (1977).
- 22.
Levine, L. & Gutierrez-Cernosek, R. M. Prostaglandins 3, 785–804 (1973).
- 23.
Bunting, S., Moncada, S., Reed, P., Salmon, J. A. & Vane, J. R. Prostaglandins 15, 565 (1978).
- 24.
Fitzpatrick, F. A. & Gorman, R. R. Prostaglandins 15, 725 (1978).
Author information
Affiliations
Cardeza Foundation and Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
- J. BRYAN SMITH
Department of Physiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
- MARTIN L. OGLETREE
- & ALLAN M. LEFER
Chemistry Department, University of Pennsylvania, Philadelphia, Pennsylvania 19174
- KYRIACOUS C. NICOLAOU
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