Abstract
ATTEMPTS to identify an easily measured cell surface marker that would detect activation of T or B lymphocytes in a variety of species have been unsuccessful. Although insulin receptors have been identified for fat, liver, skeletal and cardiac muscle, fibroblasts and monocytes1–8, quiescent rat splenic T lymphocytes do not bear such receptors. However, insulin receptors do emerge on T lymphocytes after concanavalin A treatment or allogeneic skin grafting9,10. Following our work on characterising a lymphocyte insulin receptor which participates in the modulation of immune response11, we have examined and report here the possibility that the emergence of a membrane-bound receptor for the peptide hormone insulin may be a universal marker for activated T and B lymphocytes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Freychet, P., Roth, J. & Neville, D. M., Jr Proc. natn. Acad. Sci. U.S.A. 68, 1833–1837 (1971).
Cuatrecasas, P. J. biol. Chem. 246, 6532–6542 (1971).
Cuatrecasas, P. Proc. natn. Acad. Sci. U.S.A. 69, 1277–1281 (1972).
Olefsky, J., Bacon, V. S. & Baur, S. Metabolism 25, 179–191 (1976).
Forgue, M. E. & Freychet, P. Diabetes 24, 715–723 (1975).
Gavin, J. R., III, Roth, J., Jen, P. & Freychet, P. Proc. natn. Acad. Sci. U.S.A. 69, 747–751 (1972).
Hollenberg, M. D. & Cuatrecasas, P. J. biol. Chem. 250, 3845–3853 (1975).
Schwartz, R. H., Bianco, A. R., Handwerger, B. S. & Kahn, C. R. Proc. natn. Acad. Sci. U.S.A. 72, 474–478 (1975).
Krug, U., Krug, F. & Cuatrecasas, P. Proc. natn. Acad. Sci. U.S.A. 69, 2604–2608 (1972).
Helderman, J. H. & Strom, T. B. J. clin. Invest. 59, 334–338 (1977).
Strom, T. B., Bear, R. A. & Carpenter, C. B. Science 187, 1206–1208 (1975).
Gammeltoft, S. & Gliemann, J. Biochim. biophys. Acta 320, 16–32 (1973).
Cuatrecasas, P. Proc. natn. Acad. Sci. U.S.A. 63, 450–457 (1969).
Yoshida, T. P. & Anderson, B. Scand. J. Immun. 1, 401 (1972).
Brown, G. & Greaves, M. J. Eur. J. Immun. 4, 302–310 (1974).
Moretta, L., Webb, S. R., Grossi, C. E., Lydyard, P. M. & Cooper, M. J. exp. Med. (in the press).
Feeney, A. J. & Hämmerling, U. Immunogenetics 3, 369–377 (1976).
Feeney, A. J. & Hämmerling, U. J. Immun. 118, 1488–1494 (1977).
Helderman, J. H. & Strom, T. B. Clin. Res. 25, 484A (1977).
Cheng, Y. & Prusoff, W. H. Biochem. Pharmac. 22, 3099–3108 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HELDERMAN, J., STROM, T. Specific insulin binding site on T and B lymphocytes as a marker of cell activation. Nature 274, 62–63 (1978). https://doi.org/10.1038/274062a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/274062a0
This article is cited by
-
Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities
Nature Reviews Endocrinology (2022)
-
Obesity and COVID-19: what makes obese host so vulnerable?
Immunity & Ageing (2021)
-
Early adaptive changes in chronic paraplegic mice: a model to study rapid health degradation after spinal cord injury
Spinal Cord (2008)
-
Na+/H+ antiporter properties in peripheral blood lymphocytes from normotensive obese and type 2 diabetic patients do not differ significantly from controls
Acta Diabetologica (1992)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.