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Monoclonal antibodies against human lymphocyte antigens

Abstract

MONOSPECIFIC antibodies produced by clones derived from appropriate hybridomas represent a new immunological tool of great analytical potential1,2. In this report several antibodies against different surface antigens of human lymphocytes are described. They were obtained and isolated as individual monoclonal products after fusion of splenocytes from an immunised mouse with a mouse myeloma line.

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References

  1. Köhler, G. & Milstein, C. Eur. J. Immun. 6, 511–519 (1976).

    Article  Google Scholar 

  2. Galfré, G., Howe, S. C., Milstein, C., Butcher, G. W. & Howard, J. C. Nature 266, 550–552 (1977).

    Article  ADS  Google Scholar 

  3. Köhler, G., Howe, S. C. & Milstein, C. Eur. J. Immun. 6, 292–295 (1976).

    Article  Google Scholar 

  4. Trucco, M., Galfré, G., De Marchi, M., Varetto, O. & Carbonara, A. O. Tissue Antigens 10, 343–344 (1977).

    Article  CAS  Google Scholar 

  5. Littlefield, J. W. Science 145, 709 (1964).

    Article  ADS  CAS  Google Scholar 

  6. Levy, R. & Dilley, J. J. Immun. 119, 387–393 (1977).

    CAS  PubMed  Google Scholar 

  7. Stocker, J. W., Ceppelini, R. & Trucco, M. M. in Current Trends in Tumor Immunology (ed. Gorini, S.) (Firenze Fond, Menarini, in the press).

  8. Jones, E. A., Goodfellow, P. N., Bodmer, J. G. & Bodmer, W. F. Nature 256, 650–653 (1975).

    Article  ADS  CAS  Google Scholar 

  9. Bernoco, D. et al. Tissue Antigens 8, 253–260 (1976).

    CAS  PubMed  Google Scholar 

  10. Reisfeld, R. A., Allison, J. P., Ferrone, S., Pellegrino, M. A. & Poulik, M. D. Transplant Proc. 8, 173 (1976).

    CAS  PubMed  Google Scholar 

  11. Farr, R. S. J. infect. Diseases 103, 239 (1958).

    Article  CAS  Google Scholar 

  12. Gearhart, P. J. Nature 269, 812–813 (1977).

    Article  ADS  CAS  Google Scholar 

  13. Laemmli, U. K. & Faure, M. J. molec. Biol. 80, 575–599 (1973).

    Article  CAS  Google Scholar 

  14. Cotton, R. G. H., Secher, D. S. & Milstein, C. Eur. J. Immun. 3, 135–140 (1973).

    Article  CAS  Google Scholar 

  15. Lampson, L., Levy, R., Grumet, F. C., Ness, D. & Pious, D. Nature 271, 461–462 (1978).

    Article  ADS  CAS  Google Scholar 

  16. Sanderson, A. Nature 269, 414–415 (1977).

    Article  ADS  CAS  Google Scholar 

  17. Minowada, J., Ohnuma, T. & Miller, G. J. Virol. 6, 699–701 (1970).

    Google Scholar 

  18. Rogentine, G. N. Histocompatibility Testing 1967, 371–379 (Munksgaard, Copenhagen, 1967).

    Google Scholar 

  19. Bodmer, W. F., Tripp, M. & Bodmer, J. G. Histocompatibility Testing 1967, 341–350 (Munksgaard, Copenhagen, 1967).

    Google Scholar 

  20. Mottironi, V. D. & Terasaki, P. I. Histocompatibility Testing 1970, 301–307 (Munksgaard, Copenhagen, 1970).

    Google Scholar 

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TRUCCO, M., STOCKER, J. & CEPPELLINI, R. Monoclonal antibodies against human lymphocyte antigens. Nature 273, 666–668 (1978). https://doi.org/10.1038/273666a0

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