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Nucleotide sequence of cro, cII and part of the O gene in phage λ DNA

Nature volume 272, pages 410–414 (1978)Cite this article

Abstract

A nucleotide sequence comprising 960 base pairs of bacteriophage λDNA has been determined. The sequence includes the entire genes of the regulatory proteins cro and cII, and part of the O gene, together with control elements for their transcription and translation. The right-hand boundaries of the λimm434 and λimm21 substitutions and the cy42 mutation have been located.

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References

  1. Herskowitz, I. A. Rev. Gen. 7, 289–324 (1974).

    Article  Google Scholar 

  2. Pirrotta, V. Curr. Top. Microbiol. Immun. 74, 21–54 (1976).

    CAS  Google Scholar 

  3. Roberts, J. W. Nature 224, 1168–1174 (1969); Proc. natn. Acad. Sci. U.S.A. 72, 3300–3304 (1975).

    Article  ADS  CAS  Google Scholar 

  4. Reichardt, L. & Kaiser, A. D. Proc. natn. Acad. Sci. U.S.A. 68, 2185–2189 (1971).

    Article  ADS  CAS  Google Scholar 

  5. Echols, H. & Green, L. Proc. natn. Acad. Sci. U.S.A. 68, 2190–2194 (1971).

    Article  ADS  CAS  Google Scholar 

  6. Reichardt, L. J. molec. Biol. 93, 267–309 (1975).

    Article  CAS  Google Scholar 

  7. Honigman, A., Hu, S.-L., Chase, R. & Szybalski, W. Nature 262, 112–116 (1976).

    Article  ADS  CAS  Google Scholar 

  8. Walz, A., Pirrotta, V. & Ineichen, K. Nature 262, 665–669 (1976).

    Article  ADS  CAS  Google Scholar 

  9. Eisen, H., Pereira da Silva, L. & Jacob, F. C. hebd. Seanc. Acad. Sci., Paris 266, 1176–1178 (1968).

    CAS  Google Scholar 

  10. Brachet, P. & Thomas, R. Mutat. Res. 7, 257–260 (1969).

    Article  CAS  Google Scholar 

  11. Streeck, R. E. & Hobom, G. Eur. J. Biochem. 57, 595–606 (1975).

    Article  CAS  Google Scholar 

  12. Maxam, A. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).

    Article  ADS  CAS  Google Scholar 

  13. Donelson, J. E. & Wu, R. J. biol. Chem. 247, 4654–4660 (1972).

    CAS  PubMed  Google Scholar 

  14. Kössel, H., Roychoudhury, R., Fischer, D. & Otto, A. in Methods in Enzymology Vol. 29E (eds Grossmann, L. & Moldave, K.) 322–341 (1974).

    Google Scholar 

  15. Roychoudhury, R., Jay, E. & Wu, R. Nucleic Acids Res. 3, 863–877 (1976).

    Article  CAS  Google Scholar 

  16. Shine, J. & Dalgarno, L. Proc. natn. Acad. Sci. U.S.A. 71, 1342–1346 (1974).

    Article  ADS  CAS  Google Scholar 

  17. Steitz, J. A. & Jakes, K. Proc. natn. Acad. Sci. U.S.A. 72, 4734–4738 (1975).

    Article  ADS  CAS  Google Scholar 

  18. Steege, D. J. molec. Biol. 114, 559–568 (1977).

    Article  CAS  Google Scholar 

  19. Belfort, M., Noff, D. & Oppenheim, A. B. Virology 63, 147–159 (1975).

    Article  CAS  Google Scholar 

  20. Yates, J. L., Gette, W. R., Furth, M. E. & Nomura, M. Proc. natn. Acad. Sci. U.S.A. 74, 689–693 (1977).

    Article  ADS  CAS  Google Scholar 

  21. Wulff, D. L. Genetics 82, 401–416 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Kaiser, A. D. Virology 3, 42–61 (1957).

    Article  CAS  Google Scholar 

  23. Matsubara, K. J. molec. Biol. 102, 427–439 (1976).

    Article  CAS  Google Scholar 

  24. Steitz, J. A. in Biological Regulation and Control (ed. Goldberger, R.) (Plenum, New York, in the press).

  25. Bertrand, K. et al. Science 189, 22–26 (1975).

    Article  ADS  CAS  Google Scholar 

  26. Sklar, J., Yot, P. & Weissmann, S. M. Proc. natn. Acad. Sci. U.S.A. 72, 1817–1821 (1975).

    Article  ADS  CAS  Google Scholar 

  27. Pieczenik, G., Barrell, B. G. & Gefter, M. L. Archs Biochem. Biophys. 152, 152–165 (1972).

    Article  CAS  Google Scholar 

  28. Sugimoto, K., Sugisaki, H., Okamoto, T. & Takanami, M. J. molec. Biol. 111, 487–507 (1977).

    Article  CAS  Google Scholar 

  29. Gilbert, W. in RNA Polymerase (eds Losick, R. & Chamberlin, M.) 193–205 (Cold Spring Harb. Lab., New York, 1976).

    Google Scholar 

  30. Szybalski, W. in Handbook of Biochemistry and Molecular Biology, 3rd edn (ed. Fasman, G. D.) 677–685 (CRC, Cleveland, 1976).

    Google Scholar 

  31. Thomas, M. & Davis, R. W. J. molec. Biol. 91, 315–328 (1975).

    Article  CAS  Google Scholar 

  32. Maniatis, T. et al. Cell 5, 109–113 (1975).

    Article  CAS  Google Scholar 

  33. Rosenberg, M. De Crombrugghe, B. & Musso, R. Proc. natn. Acad. Sci. U.S.A. 73, 717–721 (1976).

    Article  ADS  CAS  Google Scholar 

  34. Scherer, G., Hobom, G. & Kössel, H. Nature 265, 117–121 (1977).

    Article  ADS  CAS  Google Scholar 

  35. Westmoreland, B. C., Szybalski, W. & Ris, H. Science 163, 1343–1348 (1969).

    Article  ADS  CAS  Google Scholar 

  36. Kaiser, A. D. & Jacob, F. Virology 4, 509–521 (1957).

    Article  CAS  Google Scholar 

  37. Kleid, D., Humayun, Z., Jeffrey, A. & Ptashne, M. Proc. natn. Acad. Sci. U.S.A. 73, 293–297 (1976).

    Article  ADS  CAS  Google Scholar 

  38. Slater, J. P., Tamir, I., Loeb, L. A. & Mildvan, A. S. J. biol. Chem. 247, 6784–6794 (1972).

    CAS  PubMed  Google Scholar 

  39. Hsiang, M. W., Cole, R. D., Takeda, Y. & Echols, H. Nature 270, 275–277 (1977).

    Article  ADS  CAS  Google Scholar 

  40. Roberts, T. M. Shimatake, H., Brady, C. & Rosenberg, M. Nature 270, 274–275 (1977).

    Article  ADS  CAS  Google Scholar 

  41. Dahlberg, J. F., & Blatther, E. R. in Virus Research (eds Fox, C. F. & Robinson, W. S.) 533–543 (Academic, New York, 1973).

    Google Scholar 

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Authors and Affiliations

  1. Institut für Biologie III der Universität Freiburg, D-7800, Freiburg i.Br., FRG

    E. Schwarz, G. Scherer, G. Hobom & H. Kössel

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  1. E. Schwarz
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  2. G. Scherer
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  3. G. Hobom
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  4. H. Kössel
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Schwarz, E., Scherer, G., Hobom, G. et al. Nucleotide sequence of cro, cII and part of the O gene in phage λ DNA. Nature 272, 410–414 (1978). https://doi.org/10.1038/272410a0

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