Abstract
THE effect of dose fractionation on oncogenic transformation can be studied quantitatively by using recently developed cell lines in which transformation is scored by the loss of contact inhibition1,2. We report here that splitting the dose into two fractions enhances oncogenic transformation at low doses, whereas at high doses fractionation results in less effect than the same total dose in a single exposure. This observation is pertinent to the calculation of cancer risk estimates for multiple low-dose exposures, to which radiation workers or members of the general public are exposed, by means of a linear extrapolation from observed human data at high dose levels.
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MILLER, R., HALL, E. X-ray dose fractionation and oncogenic transformations in cultured mouse embryo cells. Nature 272, 58–60 (1978). https://doi.org/10.1038/272058a0
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DOI: https://doi.org/10.1038/272058a0
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