Abstract
Smith et al. reply — Morrowet al.are incorrect to state that we did not provide direct evidence that 3α-OH-5α-pregnan-20-one (3α,5α-THP, or allopregnanolone) levels were reduced by indomethacin. We pointed out1 that our previous studies7 showed that indomethacin administration concomitant with progesterone reduced the level of 3α,5α-THP in the central nervous system from 8.2 6 1.3 ng per g to 2.3 0.35 ng per g without altering levels of 5α-DHP or progesterone. This treatment, which prevented the withdrawal of 3α,5α-THP that normally accompanies progesterone withdrawal, completely prevented the withdrawal effects of progesterone we observed1, including acceleration in the decay of GABA-gated current and upregulation of the GABAA-receptor α4 subunit.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Smith, S. S. et al. Nature 392, 926–930 (1998).
Bjurulf, E., Selstam, G. & Olofsson, J. . J. Reprod. Fertil. 102, 139–145 (1994).
Uzunov, D. P., Cooper, T. B., Costa, E. & Guidotti, A. Proc. Natl Acad. Sci. USA 93, 12599–12604 (1996).
Devaud, L. L., Purdy, R. H., Finn, D. A. & Morrow, A. L. J. Pharmacol. Exp. Ther. 278, 510–517 (1996).
Devaud, L. L., Purdy, R. H. & Morrow, A. L. Alcohol. Clin. Exp. Res. 19, 350–355 (1995).
Devaud, L. L., Fritschy, J. M., Sieghart, W. & Morrow, A. L. J. Neurochem. 69, 126–130 (1997).
Costa, A. M., Spence, K. T., Smith, S. S. & ffrench-Mullen, J. M. H. J. Neurophysiol. 74, 464–469 (1995).
Smith, S. S. et al. J. Neurosci. 18, 5275–5284 (1998).
Penning, T. M., Sharp, R. B. & Krieger, N. R. J. Biol. Chem. 260, 15266–15272 (1985).
Bernardi, F. et al. Eur. J. Endocrinol. 138, 316–321 (1998).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Smith, S., Gong, Q., Hsu, FC. et al. Effects of progesterone or neuroactive steroid?. Nature 395, 652–653 (1998). https://doi.org/10.1038/27109
Issue Date:
DOI: https://doi.org/10.1038/27109
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
