Abstract
DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.
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Rothenberg, E., Smotkin, D., Baltimore, D. et al. In vitro synthesis of infectious DNA of murine leukaemia virus. Nature 269, 122–126 (1977). https://doi.org/10.1038/269122a0
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DOI: https://doi.org/10.1038/269122a0
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