Abstract
THE immune complex renal disease of NZB/W mice is largely prevented and survival of the animals markedly prolonged by protein or calorie restriction1,2. These same dietary restrictions depress the antibody response3–7 and inhibit the development of spontaneous cancer8–10 in experimental animals. Spontaneous release of endogenous type C viruses (MuLV) and the autogenous host humoral immune response to these MuLV have been implicated in the aetiology of autoimmune disease in NZB and (NZB × NZW)F1 (B/W) mice11–14. We wondered whether the disease-sparing effect of a low protein diet in B/W mice was attributable to a decrease in the production of endogenous MuLV or a reduction in the host response to this virus. Our findings suggest that neither of these events is responsible for the disease prevention.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dubois, E. & Strain, L. Biochem. Med. 7, 336–342 (1973).
Fernandes, G., Yunis, E. J. & Good, R. A. Proc. natn. Acad. Sci. U.S.A. 73, 1279–1283 (1976).
Cooper, W. C., Good, R. A. & Mariani, T. Am. J. clin. Nutr. 27, 647–664 (1974).
Aschkenasy, A. Nature 250, 325–327 (1974).
Aschkenasy, A. Nature 254, 63–65 (1975).
Fernandes, G., Yunis, E. J. & Good, R. A. J. Immun. 116, 782–790 (1976).
Coovadia, H. M. & Soothill, J. F. Clin. exp. Immun. 23, 562–567 (1976).
Saxton, J. A., Boon, M. C. & Furth, J. Cancer Res. 4, 401–409 (1944).
Fernandes, G., Yunis, E. J. & Good, R. A. Nature 263, 504–507 (1976).
Heston, W. E. & Vlahakis, G. J. natn. Cancer Inst. 27, 1189–1196 (1961).
Mellors, R. C., Shirai, T., Aoki, T., Huebner, R. J. & Krawczynski, K. J. exp. Med. 133, 113–132 (1971).
Mellors, R. C., Aoki, T. & Huebner, R. J. J. exp. Med. 129, 1045–1062 (1969).
Levy, J. A. Am. J. clin. Path. 62, 258–280 (1974).
Levy, J. A. Rheumatology 2, 135–148 (1975).
Dubois, E. L., Horowitz, R. E., Demopoulos, H. B. & Teplitz, R. J. Am. med. Ass. 195, 285–289 (1966).
Peto, R. Br. J. Cancer 29, 101–105 (1975).
Levy, J. A. & Pincus, T. Science 170, 326–327 (1970).
Levy, J. A. Science 182, 1151–1153 (1973).
Yoskihi, T., Mellors, R. C., Strand, M. & August, J. T. J. exp. Med. 140, 1011–1027 (1974).
Lee, J. C. & Ihle, J. N. J. natn. Cancer Inst. 55, 831–838 (1975).
Strand, M. & August, J. T. Virology, 75, 130–144 (1976).
Leong, J., Kane, J., Oleszko, O. & Levy, J. Proc. natn. Acad. Sci. U.S.A. 74, 276–280 (1977).
Levy, J. A., Ihle, J. N., Oleszko, O. & Barnes, R. D. Proc. natn. Acad. Sci. U.S.A. 72, 5071–5075 (1975).
Nowinski, R. C. & Kaehler, S. L. Science 185, 869–871 (1974).
Datta, S. K. & Schwartz, R. S. Nature 263, 412–414 (1976).
Dixon, F. J., Oldstone, M. B. A. & Tonietti, G. J. exp. Med. 134, 65s–71s (1971).
Levy, J. A., Kazan, P., Varnier, O. & Kleiman, H. J. Virol. 16, 844–853 (1975).
Rowe, W. P., Pugh, W. E. & Hartley, J. W. Virology 42, 1136–1139 (1970).
Talal, N., Pillarisetty, R. J., DeHoratius, R. J. & Messner, R. Clin. exp. Immun. 25, 377–382 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GARDNER, M., IHLE, J., PILLARISETTY, R. et al. Type C virus expression and host response in diet-cured NZB/W mice. Nature 268, 341–344 (1977). https://doi.org/10.1038/268341a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/268341a0
This article is cited by
-
Nutrition and immunity
Journal of Clinical Immunology (1981)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
