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Prostaglandin E2-9-ketoreductase as a mediator of salt intake-related prostaglandin-renin interaction

Nature volume 266, pages 65–66 (1977)Cite this article

Abstract

PREVIOUS studies have revealed a close relationship between the prostaglandin (PG) and the renin–angiotensin systems in the kidney1–4 and we assume that both systems are intimately involved in the regulation of salt and volume homeostasis and of blood pressure. Changes in NaCl and water balance were found to be important determinants of the activity and function of the renin–angiotensin system5 and it has been suggested that PG synthesis is also modified by these variables2,6,7. One factor influencing the pathway and, thus, the consequences of altered PG formation is the enzyme PGE2-9-ketoreductase, which catalyses the interconversion of the antagonistically acting PGE2 and PGF2α (ref. 8). First direct evidence is presented here that PGE2-9-ketoreductase activity is under the control of NaCl ingestion. We suggest that this enzyme is an important mediator of salt intake-related prostaglandin–renin interaction.

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  1. Department of Internal Medicine, University Hospital, Ziemssenstrasse 1, 8000, Munich, 2, West Germany

    PETER C. WEBER, CARIN LARSSON & BURKHARD SCHERER

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WEBER, P., LARSSON, C. & SCHERER, B. Prostaglandin E2-9-ketoreductase as a mediator of salt intake-related prostaglandin-renin interaction. Nature 266, 65–66 (1977). https://doi.org/10.1038/266065a0

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