Abstract
CELL surface changes accompanying malignancy may result in the expression by the tumour cells of antigens recognisable by the host's immune system. It is interesting to know whether nascent tumours express common tumour-associated antigens and what, if any, is the relationship of these antigens to histocompatibility alloantigens. We have addressed these questions by testing a series of early passage, transplacentally induced murine lung tumours for a cross-reactive histocompatibility locus-coded alloantigen. A common transplantation alloantigen was readily detected on six of 15 lung tumours tested.
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MARTIN, W., GIPSON, T. & RICE, J. H–2a-associated alloantigen expressed by several transplacentally-induced lung tumours of C3Hf mice. Nature 265, 738–739 (1977). https://doi.org/10.1038/265738a0
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DOI: https://doi.org/10.1038/265738a0
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