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Regulation of autosensitisation to encephalitogenic myelin basic protein by macrophage-associated and soluble antigen

Abstract

AUTOIMMUNE diseases are characterised by an attack of an individual's lymphocytes against his own body's components, self-antigens. The immunogenicity of self-antigens can be defined operationally by their capacity to trigger lymphocytes bearing specific receptors. We have designed experiments to learn how a defined self-antigen can function as an immunogen in vitro and how the form of its presentation to self-recognising lymphocytes may abrogate this immunogenicity. We have found that myelin basic protein (BP) behaves as a self-immunogen when presented to lymphocytes by way of syngeneic macrophages. Moreover, recognition of this self-immunogen can be inhibited by the presence of the same self-antigen in soluble form during the primary lymphocyte–macrophage interaction.

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References

  1. Hashim, G. A., and Eylar, E. H., Archs Biochem. Biophys., 129, 645–654 (1969).

    Article  CAS  Google Scholar 

  2. Paterson, P. Y., Adv. Immun., 5, 131–208 (1966).

    Article  CAS  Google Scholar 

  3. Rauch, H. C., Raffel, H. S., and Roboz-Einstein, E., J. Immun., 102, 1431–1436 (1969).

    CAS  PubMed  Google Scholar 

  4. Levine, S., Honig, E. M., and Kies, M. W., Science, 161, 1155–1157 (1968).

    Article  ADS  CAS  Google Scholar 

  5. Teitelbaum, D., Webb, C., Meshorer, A., Arnon, R., and Sela, M., Nature, 240, 564–566 (1972).

    Article  ADS  CAS  Google Scholar 

  6. Cohen, I. R., Nature new Biol., 242, 60–61 (1973).

    Article  ADS  CAS  Google Scholar 

  7. Yung, L. L. L., Diener, E., McPherson, A., Barton, M. A., and Hyde, H. A., J. Immun., 110, 1383–1387 (1973).

    CAS  PubMed  Google Scholar 

  8. Orgad, S., and Cohen, I. R., Science, 183, 1083–1085 (1974).

    Article  ADS  CAS  Google Scholar 

  9. Unanue, E. R., Askonas, B. A., and Allison, A. C., J. Immun., 103, 71–77 (1969).

    CAS  PubMed  Google Scholar 

  10. Treves, A. J., Schechter, B., Cohen, I. R., and Feldman, M., J. Immun., 116, 1059–1064 (1976).

    CAS  PubMed  Google Scholar 

  11. Unanue, E. R., Adv. Immun., 15, 95–165 (1972).

    Article  CAS  Google Scholar 

  12. Cohen, I. R., and Wekerle, H., J. exp. Med., 137, 224–238 (1973).

    Article  CAS  Google Scholar 

  13. Wekerle, H., Cohen, I. R., and Feldman, M., Nature new Biol., 241, 25–26 (1973).

    Article  CAS  Google Scholar 

  14. Forni, G., and Green, I., J. Immun., 116, 1561–1565 (1976).

    CAS  PubMed  Google Scholar 

  15. Wekerle, H., and Begemann, M., J. Immun., 116, 159–177 (1976).

    CAS  PubMed  Google Scholar 

Download references

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STEINMAN, L., COHEN, I., TEITELBAUM, D. et al. Regulation of autosensitisation to encephalitogenic myelin basic protein by macrophage-associated and soluble antigen. Nature 265, 173–175 (1977). https://doi.org/10.1038/265173a0

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