Abstract
AUTOIMMUNE diseases are characterised by an attack of an individual's lymphocytes against his own body's components, self-antigens. The immunogenicity of self-antigens can be defined operationally by their capacity to trigger lymphocytes bearing specific receptors. We have designed experiments to learn how a defined self-antigen can function as an immunogen in vitro and how the form of its presentation to self-recognising lymphocytes may abrogate this immunogenicity. We have found that myelin basic protein (BP) behaves as a self-immunogen when presented to lymphocytes by way of syngeneic macrophages. Moreover, recognition of this self-immunogen can be inhibited by the presence of the same self-antigen in soluble form during the primary lymphocyte–macrophage interaction.
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STEINMAN, L., COHEN, I., TEITELBAUM, D. et al. Regulation of autosensitisation to encephalitogenic myelin basic protein by macrophage-associated and soluble antigen. Nature 265, 173–175 (1977). https://doi.org/10.1038/265173a0
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DOI: https://doi.org/10.1038/265173a0
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