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T4 Bacteriophage-coded RNA polymerase subunit blocks host transcription and unfolds the host chromosome

Abstract

T4 bacteriophage mutants selected for their ability to grow with cytosine in their DNA are defective in host transcriptional shutoff and host chromosome unfolding. The host RNA polymerase purified from cells infected by such a mutant lacks a small T4-coded subunit.

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Sirotkin, K., Wei, J. & Snyder, L. T4 Bacteriophage-coded RNA polymerase subunit blocks host transcription and unfolds the host chromosome. Nature 265, 28–32 (1977). https://doi.org/10.1038/265028a0

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