Abstract
THE major histocompatibility complex (MHC) of mouse, man and other species has attracted much attention recently, and that of the mouse is perhaps the most precisely studied mammalian genetic region (reviewed in refs 1–3). Within the space of 0.5 centimorgans are genes coding for transplantation antigens present on essentially all cells (H–2K and H–2D); genes influencing immune responses (“immune response or Ir genes”); genes coding for surface alloantigens of restricted tissue distribution (immune response gene region associated antigens or Ia antigens); genes influencing cell interactions, the production of factors and stimulation in the mixed lymphocyte reaction (all in the I region and its subregions I-A, I-B, I-C and so on), as well as genes controlling serum proteins related to complement (S region), and red-cell antigens. Although the products of some of these genetic regions are clear (for example, of the H–2K or H–2D loci) this is not the case for the I region which influences many immune functions, such as delayed hyper-sensitivity4 and antibody production5. One group of products of the I region genes constitutes the la antigens which have been defined by alloantisera6,7. Other products of these genes are still elusive, and some authors have even suggested that I region gene products are antigen-specific receptors on T cells8,9.
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ERB, P., MEIER, B. & FELDMANN, M. Two-gene control of T-helper cell induction. Nature 263, 601–604 (1976). https://doi.org/10.1038/263601a0
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DOI: https://doi.org/10.1038/263601a0
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