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Transformation of thymocytes by thymus epithelium derived from AKR mice

Nature volume 263, pages 512–514 (1976)Cite this article

Abstract

TYPE C RNA viruses result in the appearance of lymphomas and leukaemias when injected into genetically susceptible strains of mice1. The relationship between the murine leukaemia viruses (MuLV) and their target cells in the induction of leukaemia remains, however, incompletely defined. Although MuLV viruses are ubiquitous in the tissues of many mouse strains and are present throughout the life of the animal, they transform specific haemopoietic cell types into leukaemic cells only after a relatively long latent period2–5. This suggests that leukaemia is not caused by the virus alone but that a special interaction exists between viruses and target cells in a particular stage of differentiation and maturation.

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Authors and Affiliations

  1. Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 25014

    SAMUEL D. WAKSAL

  2. Weizmann Institute of Science, Rehovot, Israel

    S. SMOLINSKY, I. R. COHEN & M. FELDMAN

Authors
  1. SAMUEL D. WAKSAL
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  2. S. SMOLINSKY
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  3. I. R. COHEN
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  4. M. FELDMAN
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WAKSAL, S., SMOLINSKY, S., COHEN, I. et al. Transformation of thymocytes by thymus epithelium derived from AKR mice. Nature 263, 512–514 (1976). https://doi.org/10.1038/263512a0

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