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Relationships between structure and activity of retinoids

Nature volume 263, pages 110–113 (1976)Cite this article

Abstract

Structure–function relationships of 19 retinoids were studied in three in vitro systems in defined, serum-free medium. These systems measure effects on differentiation and growth, as well as toxic effects. The ring, side chain, and polar terminal group of natural retinoids all may be modified synthetically to yield highly active compounds. Several retinoid ethers were found to be significantly less toxic than the corresponding carboxylic acids or alcohols.

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Authors and Affiliations

  1. Lung Cancer Branch, Carcinogenesis Program, National Cancer Institute, Bethesda, Maryland, 20014

    Michael B. Sporn, Nancy M. Dunlop, Dianne L. Newton & William R. Henderson

Authors
  1. Michael B. Sporn
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  2. Nancy M. Dunlop
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  3. Dianne L. Newton
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  4. William R. Henderson
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Sporn, M., Dunlop, N., Newton, D. et al. Relationships between structure and activity of retinoids. Nature 263, 110–113 (1976). https://doi.org/10.1038/263110a0

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