Abstract
PATHOLOGICAL bone breakdown may be stimulated by some tissues proximal to bone and the release of collagenase by them may be one cause of this lysis. Inflamed gingivae, for example, have been shown to lyse collagen gels1,2 and are associated with the loss of bone in periodontal disease. The ability of human mammary carcinomas to break down bone in vitro3,4 has been shown to be caused, in part, by prostaglandin release by the tumours5 and, in part, by their release of an osteolytically active, non-dialysable material (unpublished results). The possibility that the latter might be collagenolytic in nature was suggested by reports that some neoplasms release collagenolytic activity in vitro6–9. This prompted our present study of the mechanism of bone breakdown by exogenous collagenase. The investigation has shown that prostaglandin synthesis by bone cells is probably a necessary mediatory step in collagenase-induced bone resorption.
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DOWSETT, M., EASTMAN, A., EASTY, D. et al. Prostaglandin mediation of collagenase-induced bone resorption. Nature 263, 72–74 (1976). https://doi.org/10.1038/263072a0
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DOI: https://doi.org/10.1038/263072a0
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