Abstract
The microsomal fraction of horse and human platelets contains an enzyme which converts prostaglandin cyclic endoperoxides (PGG2 or PGH2) to a substance which is much more potent in contracting strips of rabbit aorta. This substance has the same characteristics as thromboxane A2, and can be distinguished from other products of arachidonic acid metabolism by differential bioassay.
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References
Piper, P. J., and Vane, J. R., Nature, 223, 29–35 (1969).
Piper, P. J., and Vane, J. R., Ann. N. Y. Acad. Sci., 180, 363–385 (1971).
Vargaftig, B. B., and Dao, N., Pharmacology, 6, 99–108 (1971).
Palmer, M. A., Piper, P. J., and Vane, J. R., Br. J. Pharmac., 49, 226–242 (1973).
Gryglewski, R., and Vane, J. R., Br. J. Pharmac., 46, 449–457 (1972).
Willis, A. L., Circulation, 48, Suppl. 4, 55 (1973).
Willis, A. L., Science, 183, 325–327 (1974).
Vargaftig, B. B., and Zirinis, P., Nature new Biol., 244, 114–116 (1973).
Vargaftig, B. B., Tranier, Y., and Chignard, M., Prostaglandins, 8, 133–156 (1974).
Svensson, J., Hamberg, M., and Samuelsson, B., Acta physiol. scand., 94, 222–228 (1975).
Nugteren, D. H., Beerthuis, R. K., and van Dorp, D. A., Proc. Second Nobel Symp. (edit. by Bergstrom, S., and Samuelsson, B.), 45–50 (Nobel Foundation, Stockholm, 1967).
Samuelsson, B., Granstrom, E., and Hamberg, M., Proc. Second Nobel Symp. (edit. Bergstrom, S., and Samulesson, B.), 31–44 (Nobel Foundation, Stockholm, 1967).
Hamberg, M., and Samuelsson, B., Proc. natn. Acad. Sci. U.S.A., 70, 899–903 (1973).
Nugteren, D. H., and Hazelhof, E., Biochim. biophys. Acta, 326, 448–461 (1973).
Hamberg, M., Hedqvist, P., Strandberg, K., Svensson, J., and Samuelsson, B., Life Sci., 16, 451–462 (1975).
Hamberg, M., Svensson, J., Wakabayashi, T., and Samuelsson, B., Proc. natn. Acad. Sci. U.S.A., 71, 345–349 (1974).
Smith, J. B., Ingerman, C., Kocsis, J. J., and Silver, M. J., J. clin. Invest., 53, 1468–1472 (1974).
Zucker, M. B., and Peterson, J., Proc. Soc. exp. Biol. Med., 127, 547–551 (1968).
Hamberg, M., Svensson, J., and Samuelsson, B., Proc. natn. Acad. Sci. U.S.A., 72, 2994–2998 (1975).
Gornal, A. G., Bardawill, C. J., and David, M. M., J. biol. Chem., 177, 751–776 (1949).
Vane, J. R., Br. J. Pharmac., 12, 344–349 (1957).
Gilmore, N., Vane, J. R., and Wyllie, H. J., Nature, 218, 1135–1140 (1968).
Eckenfels, A., and Vane, J. R., Br. J. Pharmac., 45, 451–462 (1972).
Willis, A. K., Prostaglandins, 5, 1–25 (1974).
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Needleman, P., Moncada, S., Bunting, S. et al. Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature 261, 558–560 (1976). https://doi.org/10.1038/261558a0
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DOI: https://doi.org/10.1038/261558a0
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