Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Scientific Correspondence
  • Published:

Does vitamin C have a pro-oxidant effect?

Nature volume 395, pages 231–232 (1998)Cite this article

Abstract

Podmore et al.1 reported a decrease in 8-oxo-7,8-dihydroguanine and an increase in 8-oxo-7,8-dihydroadenine in lympho-cyte DNA after intake of 500 milligrams of vitamin C daily for 6 weeks. In our view, four issues compromise the validity of their findings.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Podmore, I. D.et al. Nature 392, 559 (1998).

    Article  ADS  CAS  Google Scholar 

  2. Cadet, J., Douki, T. & Ravanat, J.-L. Environ. Health Perspect. 105, 1034–1039 (1997).

    Google Scholar 

  3. Helbrook, H. J.et al. Proc. Natl Acad. Sci. USA 95, 288 (1998).

    Google Scholar 

  4. Collins, A., Cadet, J., Epe, B. & Gedik, C. Carcinogenesis 18, 1833–1836 (1997).

    Google Scholar 

  5. Cadenas, S., Barja, G., Poulsen, H. E. & Loft, S. Carcinogenesis 18, 2373 (1997).

    Google Scholar 

  6. Prieme, H., Loft, S., Nyssönen, K., Salonen, J. T. & Poulsen, H. E. Am. J. Clin. Nutr. 65, 503–507 (1997).

    Google Scholar 

  7. Deng, X.-S., Tuo, J., Poulsen, H. E. & Loft, S. Free Rad. Res. 28, 323–333 (1998).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology Q 7642, Rigshospitalet, University of Copenhagen, DK-2200, Copenhagen N, Denmark

    Henrik E. Poulsen & Allan Weimann

  2. Research Institute of Public Health, University of Kuopio, FIN-70211, Kuopio, Finland

    Jukka T. Salonen & Kristiina Nyyssönen

  3. Institute of Public Health, University of Copenhagen, Panum 18-5, DK-2100, Copenhagen, Denmark

    Steffen Loft

  4. DRFMC/SCIB, Laboratoire Lésions des Acides Nucléiques, CEA/Grenoble, Grenoble, F-38054 Cedex 9, France

    Jean Cadet, Thierry Douki & Jean-Luc Ravanat

Authors
  1. Henrik E. Poulsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Allan Weimann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jukka T. Salonen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kristiina Nyyssönen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Steffen Loft
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jean Cadet
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Thierry Douki
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jean-Luc Ravanat
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Poulsen, H., Weimann, A., Salonen, J. et al. Does vitamin C have a pro-oxidant effect?. Nature 395, 231–232 (1998). https://doi.org/10.1038/26139

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/26139

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing