Abstract
AFTER the discovery and isolation of β-lipotropin from sheep pituitary glands1,2, the hormone has also been obtained in highly purified form from bovine3, porcine4–6, and human7,8 pituitaries. The complete amino acid sequences of ovine9,10 and porcine11–13 hormones have been proposed. To gain insight into the evolutionary history of lipotropins and their structure–function relationships, and in view of recent data on the opiate agonist activity of peptide fragments from β-lipotropin14,15, we report here the complete amino acid sequence of the human hormone.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Li, C. H., Nature, 201, 924 (1964).
Birk, Y., and Li, C. H., J. biol. Chem., 239, 1048–1052 (1964).
Lohmar, P., and Li, C. H., Biochim. biophys. Acta, 147, 381–383 (1967).
Gráf, L., and Cseh, G., Biochim. biophys. Acta, 3, 175–177 (1968).
Gilardeau, C., and Chrétien, M., Can. J. Biochem., 48, 1017–1021 (1970).
Yudeau, M. A., and Pankov, Y. A., Probl. Endocrinol., 16, 49–51 (1970).
Cseh, G., Gráf, L., and Goth, F., FEBS Lett., 2, 42–44 (1968).
Scott, A. P., and Lowry, P. J., Biochem. J., 139, 593–602 (1974).
Li, C. H., Barnafi, L., Chrétien, M., and Chung, D., Nature, 208, 1093–1094 (1965); Li, C. H., Barnafi, L., Chrétien, M., and Chung, D., Excerpta Medica Interntl Congr. Ser., 112, 334–364 (1966).
Gráf, L., and Li, C. H., Biochem. biophys. Res. Commun., 53, 1304–1309 (1973).
Gráf, L., Barat, E., Cseh, G., and Sajgo, M., Biochim. biophys. Acta, 229, 276–278 (1971).
Gilardeau, C., and Chrétien, M., in Chemistry and Biology of Peptides (edit. by Meienhofer, J.), 609–611 (Ann Arbor Science, Publishers, Ann Arbor, Michigan, 1972).
Pankov, Y. A., and Yudaev, M. A., Biokimia, 37, 991–1031 (1972).
Hughes, J., et al., Nature, 258, 577–579 (1975).
Li, C. H., and Chung, D., Proc. natn. Acad. Sci. U.S.A. (in the press).
Moore, S., in Chemistry and Biology of Peptides (edit. by Meienhofer, J.), 629–653 (Ann Arbor Science, Publishers, Ann Arbor, Michigan, 1972).
Gray, W. R., in Methods of Enzymology, 2 (edit. by Hirs, C. H. W.), 469–475 (Academic, New York, 1967).
Li, C. H., Dixon, J. S., Lo, T. B., Schmidt, K. D., and Pankov, Y. A., Archs Biochem. Biophys., 141, 705–737 (1970).
Sairam, M. R., and Li, C. H., Biochim. biophys. Acta, 412, 70–81 (1975).
Cseh, G., Barat, E., Patthy, A., and Gráf, L., FEBS Lett., 21, 344–346 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LI, C., CHUNG, D. Primary structure of human β-lipotropin. Nature 260, 622–624 (1976). https://doi.org/10.1038/260622a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/260622a0
This article is cited by
-
Stimulation of aldosterone production by β-melanotropin
Nature (1981)
-
Chemistry and biosynthesis of pro-opiomelanocortin
Molecular and Cellular Biochemistry (1981)
-
?-Lipotropin as a factor in food motivation
Bulletin of Experimental Biology and Medicine (1981)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
