Abstract
PHARMACOLOGICAL studies on diacylphospholipids develop along two lines of investigation. In the first, preparations of liposomes are used as carriers of drugs either bound to the bilayer or entrapped inside the vesicles. Sonicated liposomes have been shown to be able to transport inhibitors or drugs to target sites in vitro1 and in vivo2. In the second, liposome preparations are administered and pharmacological effects are recorded. In this context significant effects have been observed on cholesterol distribution5. The molecular mechanism underlying the possibility of pharmacological effects in vivo by long chain diacylphospholipids is indicated by a series of investigations4–7 showing the capacity of phospholipid vesicles to fuse with cellular membrane in vitro. As a consequence of changed composition of membrane lipids, alteration in the permeability properties, transport systems and other functions of biological membranes are expected to occur. It has been shown8 that sonicated dispersion of bovine brain phospholipids can induce in mice modification of glucose distribution. Purification of lipid mixtures indicated that phosphatidylserine was one of the active components. Phosphatidylserine liposomes have shown great capability to interact in vitro with biologically active compounds (histamine9 or calcium10), with phospholipid-dependent enzymatic systems (Na+–K+-stimulated ATPase11 or tyrosine hydroxylase12), or with intact cells (enhancement of histamine release during antigen–antibody interaction13; promotion of cell fusion4). In this investigation data on phosphatidylserine-induced effects in vivo are presented.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bruni, A., Pitotti, A., Contessa, A. R., and Palatini, P., Biochem. biophys. Res. Commun., 44, 268–274 (1971).
Gregoriadis, G., FEBS Lett., 36, 292–296 (1973).
Jakai, L., and Quafordt, S. H., J. biol. Chem., 249, 5840–5844 (1974).
Papahadjopoulos, D., Poste, G., and Schaeffer, B. E., Biochim. biophys. Acta, 323, 23–42 (1973).
Martin, F., and MacDonald, R., Nature, 252, 161–163 (1974).
Papahadjopoulos, D., Mayhew, E., Poste, G., Smith, S., and Vail, W. J., Nature 252, 163–166 (1974).
Pagano, R. E., Huang, L., and Wey, C., Nature, 252, 166–167 (1974).
Bruni, A., Leon, A., Toffano, G., and Boarato, E., in Function and Metabolism of Phospholipids in Central Nervous System (edit. by Porcellati, G.), (Plenum, New York, in the press).
Abernety, D., Fitzgerald, T. J., and Walaszek, E. J., Biochem. biophys. Res. Commun., 59, 535–541 (1974).
Hauser, H., and Dawson, R. M. C., Eur. J. Biochem., 1, 61–69 (1967).
Wheeler, K. P., and Whittam, R., Nature, 225, 449–450 (1970).
Lloyd, T., and Kaufman, S., Biochem. biophys. Res. Commun., 59, 1262–1269 (1974).
Goth, A., Adams, H. R., and Knoohuizen, M., Science, 173, 1034–1035 (1971).
Lees, M. B., Meth. Enzymol., 3, 328–345 (1957).
Lowry, O. H., Passoneau, I. V., Hasselberger, F. X., and Schulz, D. W., J. biol. Chem., 239, 18–30 (1964).
Hauser, H., and Phillips, M. C., J. biol. Chem., 248, 8585–8591 (1973).
Wisse, E., and Gregoriadis, G., J. Reticuloendothel. Soc., 101, 10a (1975).
Chang, C. C., Int. J. Neuropharmac., 3, 643–649 (1964).
Tyce, G. M., and Owen, C. A., Jr, J. Neurochem., 20, 1563–1573 (1973).
Mongar, J. L., Svec, P., Br. J. Pharmac., 46, 741–752 (1972).
Leon, A., and Toffano, G., in Function and Metabolism of Phospholipids in Central Nervous System (edit. by Porcellati, G.), (Plenum, New York, in the press).
Mantovani, P., Pepeu, G., and Amaducci, L., in Function and Metabolism of Phospholipids in Central Nervous System (edit. by Porcellati, G.), (Plenum, New York, in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BRUNI, A., TOFFANO, G., LEON, A. et al. Pharmacological effects of phosphatidylserine liposomes. Nature 260, 331–333 (1976). https://doi.org/10.1038/260331a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/260331a0
This article is cited by
-
A randomized controlled trial investigating the neurocognitive effects of Lacprodan® PL-20, a phospholipid-rich milk protein concentrate, in elderly participants with age-associated memory impairment: the Phospholipid Intervention for Cognitive Ageing Reversal (PLICAR): study protocol for a randomized controlled trial
Trials (2013)
-
Effect of long-term parenteral administration of empty andl-Dopa-loaded liposomes on the turnover of dopamine and its metabolites in the striatum of mice with experimental Parkinson’s syndrome
Bulletin of Experimental Biology and Medicine (1997)
-
Modulatory effects of phosphatidylserine on the binding of muscarinic cholinergic receptor ligands
Molecular and Chemical Neuropathology (1990)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.